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Fludarabine

CAS No. : 21679-14-1

MCE 国际站：Fludarabine

产品活性：Fludarabine (F-ara-A; NSC 118218) 是一种 DNA 合成抑制剂和一种在淋巴增生性恶性肿瘤中具有抗肿瘤活性的氟化嘌呤类似物。Fludarabine 抑制细胞因子诱导的正常静止或激活淋巴细胞中 STAT1 和 STAT1 依赖性基因转录的激活。

研究领域：Cell Cycle/DNA Damage  |  Stem Cell/Wnt  |  JAK/STAT Signaling  |  Apoptosis

作用靶点：Nucleoside Antimetabolite/Analog  |  DNA/RNA Synthesis  |  STAT  |  Apoptosis

In Vitro: Fludarabine (5 μM; 48 hours) induces a decrease in p27kip1 expression.

In Vivo: Fludarabine (0.8 mg/kg; i.p.; two cycles for 5 days every 2 weeks) in combination with Cyclophosphamide (400 mg/kg; i.p.; 2 weeks) decreases incidence of GVHD.

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