MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Metformin hydrochloride

CAS No. : 1115-70-4

MCE 国际站：Metformin hydrochloride

产品活性：Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) 抑制肝脏中的线粒体呼吸链，导致 AMPK 活化，增强胰岛素敏感性，可用于 2 型糖尿病的研究。Metformin hydrochloride 可以透过血脑屏障，诱导自噬 (autophagy)。

研究领域：Epigenetics  |  PI3K/Akt/mTOR  |  Autophagy

作用靶点：AMPK  |  Autophagy  |  Mitophagy

In Vitro: Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) inhibits proliferation of ESCs in a concentration-dependent manner. The IC₅₀ is 2.45 mM for A-ESCs and 7.87 mM for N-ESCs. Metformin shows pronounced effects on activation of AMPK signaling in A-ESCs from secretory phase than in cells from proliferative phase.
Metformin hydrochloride (0-500 μM) decreases glycogen synthesis in a dose-dependent manner with an IC₅₀ value of 196.5 μM in cultured rat hepatocytes.
Metformin hydrochloride shows cell viability and cytotoxic effects on PC-3 cells with IC₅₀ of 5 mM.

In Vivo: Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride; 100 mg/kg, p.o.) alone, and metformin (25, 50, 100 mg/kg) with NSC 37745 groups attenuates myocyte necrosis through histopathological analysis.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Epigenetics Compound Library  |  PI3K/Akt/mTOR Compound Library  |  FDA-Approved Drug Library  |  Anti-Cancer Compound Library  |  Antiviral Compound Library  |  CNS-Penetrant Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Antioxidant Compound Library  |  Anti-diabetic Compound Library  |  Oxygen Sensing Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  Anti-COVID-19 Compound Library  |  NMPA-Approved Drug Library  |  Glycolysis Compound Library  |  Cytoskeleton Compound Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Cancer Metabolism Compound Library  |  Anti-Obesity Compound Library  |  Mitochondria-Targeted Compound Library  |  Lipid Metabolism Compound Library   |  Glucose Metabolism Compound Library  |  Rare Diseases Drug Library  |  Children’s Drug Library  |  EMA-Approved Drug Library  |  FDA-Approved Anticancer Drug Library  |  Human Metabolite Library  |  Anti-Prostate Cancer Compound Library  |  Non-steroidal Anti-Inflammatory Compound Library  |  Anti-Aging Natural Product Library  |  Pain-Related Compound Library  |  Off-patent Drug Library  |  Mitochondrial Protection Compound Library  |  Cell Death Library  |  Radioprotector Library  |  Bioactive Compound Library Max  |  3-Methyladenine  |  Doxorubicin hydrochloride  |  Olaparib  |  Dexamethasone  |  Dorsomorphin  |  Etoposide  |  Mdivi-1  |  Ruxolitinib  |  Brefeldin A  |  Adezmapimod  |  Metformin  |  Quercetin  |  AICAR  |  Resveratrol  |  Curcumin  |  Vorinostat  |  Simvastatin  |  Melatonin  |  Valproic acid  |  Hemin  |  U0126-EtOH  |  Sunitinib  |  Celastrol  |  ABT-737  |  Kaempferol  |  Tanespimycin  |  Sulfosuccinimidyl oleate sodium  |  Aspirin  |  A-769662

热门产品线：重组蛋白  |  药物筛选  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。