FITC标记的缓激肽B1受体抗体
产品名称： FITC标记的缓激肽B1受体抗体
英文名称： Anti-BDKRB1/FITC
产品编号： HZ-8675R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-BDKRB1/FITC Conjugated antibody
FITC标记的缓激肽B1受体抗体
| 产品编号 | bs-8675R-FITC |
| 英文名称 | Anti-BDKRB1/FITC |
| 中文名称 | FITC标记的缓激肽B1受体抗体 |
| 别 名 | B1 bradykinin receptor; B1BKR; B1R; BDKR B1; BDKRB 1; BDKRB1; BK 1 receptor; BK-1 receptor; bradykinin B1 R; BKB1R; BKR 1; BKR1; BKRB1_HUMAN; BRADY B1; BRADYB1; Bradykinin B1 receptor; Bradykinin receptor 1; bradykinin B1R; Bradykinin receptor B1 |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 信号转导 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 40kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from Human BDKRB1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Kinins are important biologically active peptides that mediate cardiovascular homeostasis, inflammation and nociception. Bradykinin, the major effector peptide of the kallikrein-kinin system, is regulated by angiotensin-converting enzyme (ACE), which degrades the peptide. Bradykinin normally exerts its effects through the activation of two seven transmembrane G-protein coupled receptors, named B1 and B2. The B2 receptor is constitutively expressed and preferentially binds full length bradykinin. Deletion of the B2 receptor leads to salt-sensitive hypertension and altered nociception in mice. The B1 receptor binds to derivatives of bradykinin and kallidin, which are produced by carboxypeptidase action to generate the products des-Arg9-bradykinin and des-Arg10-kallidin, respectively. The expression of the B1 receptor is inducible by inflammatory mediators, such as bacterial lipopolysaccharide (LPS) and cytokines. The B1 and B2 receptors represent potential therapeutic targets for treatment of inflammatory disorders and cardiovascular diseases. Function: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation. Subunit: Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily. Subcellular Location: Cell membrane. Similarity: Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily. Database links: Entrez Gene: 623 Human Omim: 600337 Human SwissProt: P46663 Human Unigene: 525572 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
激肽是介导心血管稳态、炎症和伤害感受性的重要生物活性肽。激肽释放酶激肽系统的主要效应肽Bradykinin是由血管紧张素转换酶（ACE）调节的，其降解肽。缓激肽通常通过激活27个跨膜G蛋白偶联受体（B1和B2）发挥作用。B2受体是组成性表达的，并优先结合全长缓激肽。B2受体的缺失导致小鼠盐敏感性高血压和伤害感受性改变。B1受体结合缓激肽和Kaldin的衍生物，它们由羧肽酶作用产生，分别产生DES-ARG9缓激肽和DES-ARG10-KALIDDIN。B1受体的表达是由炎症介质介导的，如细菌脂多糖（LPS）和细胞因子。B1和B2受体是治疗炎症性疾病和心血管疾病的潜在治疗靶点。