FITC标记的细胞分裂周期相关蛋白JPO2抗体
产品名称： FITC标记的细胞分裂周期相关蛋白JPO2抗体
英文名称： Anti-CDCA7L/FITC
产品编号： HZ-5963R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-CDCA7L/FITC Conjugated antibody
FITC标记的细胞分裂周期相关蛋白JPO2抗体
| 英文名称 | Anti-CDCA7L/FITC |
| 中文名称 | FITC标记的细胞分裂周期相关蛋白JPO2抗体 |
| 别 名 | c Myc Interacting protein JPO2; DKFZp762L0311; RAM2; HR1; JPO2; Protein JPO2; R1 antibody Transcription Factor RAM2.CDA7L_HUMAN |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 信号转导 细胞周期蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 49kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CDCA7L |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: CDCA7L is a member of the CDCA (cell division cycle associated) protein family. Members of this family have expression patterns associated with other known cell cycle genes such as cyclins and CDC genes. CDCA7L plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. It also plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. It is involved in apoptotic signaling pathways and may act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. Function: Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. Subunit: Interacts with MYC and PSIP1. Subcellular Location: Cytoplasm. Nucleus. Note=Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction. Tissue Specificity: Ubiquitous. Overexpressed in medulloblastoma. Database links: Entrez Gene: 55536 Human Omim: 609685 Human SwissProt: Q96GN5 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
CDCA7L是CDCA（细胞分裂周期相关）蛋白家族的成员。该家族成员具有与其他已知的细胞周期基因如CycLs和CDC基因相关的表达模式。CDCA7L在转录调控中起到抑制单胺氧化酶A（MAOA）活性和基因表达的抑制作用。它还参与了Myc在髓母细胞瘤细胞中的完全转化作用。它参与细胞凋亡信号通路，可能在p38激酶和bcl-2下游，但在casp3/caspase-3上游以及CCND1/cyclin D1和E2F1下游。