FITC标记的KLHDC8A蛋白抗体
产品名称： FITC标记的KLHDC8A蛋白抗体
英文名称： Anti-KLHDC8A/FITC
产品编号： HZ-8358R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-KLHDC8A/FITC Conjugated antibody
| FITC标记的KLHDC8A蛋白抗体 |
| 产品编号 | bs-8358R-FITC |
| 英文名称 | Anti-KLHDC8A/FITC |
| 中文名称 | FITC标记的KLHDC8A蛋白抗体 |
| 别 名 | Kelch domain containing 8A; Kelch domain containing protein 8A; KLHDC 8A; MGC19056; RGD1305132; A630065K24Rik; FLJ10748; KLD8A_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 39kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human KLHDC8A |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Kelch domain-containing protein 8A (KLHDC8A) is a 350 amino acid protein. KLHDC8A contains seven kelch repeats, each of which is an approximately 50 amino acid long conserved region that forms a tertiary structure beta-propeller. The gene that encodes KLHDC8A is located on chromosome 1, which is the largest human chromosome, spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes Lamin A. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. Similarity: Contains 7 Kelch repeats. Database links: UniProtKB/Swiss-Prot: Q8IYD2.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
KELCH结构域蛋白8A（KLHDC8A）是一种350氨基酸的蛋白质。KLHDC8A包含七个KalCH重复序列，每个都是一个大约50个氨基酸的长守恒区域，形成了三级结构的β螺旋桨。编码KLHDC8A的基因位于第1号染色体上，它是人类最大的染色体，跨越约2亿6000万个碱基对，占人类基因组的8%。在1号染色体上有大约3000个基因，并且考虑到大量的基因，也有大量的与染色体1相关的疾病。值得注意的是，罕见的衰老性疾病Hutchinson Gilford早老症与编码LAMNA A的LMNA基因相关。MutyH基因位于1号染色体上，部分负责家族性腺瘤性息肉病。Stutkle综合征、帕金森病、高雪氏病和Aukes综合征也与1号染色体有关。染色体1的畸变在多种癌症中发现，包括头颈部癌、恶性黑色素瘤和多发性骨髓瘤。