FITC标记的原钙粘蛋白13抗体
产品名称： FITC标记的原钙粘蛋白13抗体
英文名称： Anti-PCDHB13/FITC
产品编号： HZ-5828R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PCDHB13/FITC Conjugated antibody
FITC标记的原钙粘蛋白13抗体
| 英文名称 | Anti-PCDHB13/FITC |
| 中文名称 | FITC标记的原钙粘蛋白13抗体 |
| 别 名 | Protocadherin beta 13; PCDH BETA13; PCDHB13; PCDBD_HUMAN; Protocadherin beta-13. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 神经生物学 细胞粘附分子 细胞表面分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 84kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PCDHB13 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008] Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Subcellular Location: Cell membrane; Single-pass type I membrane protein Similarity: Contains 6 cadherin domains. Database links: Entrez Gene: 56123 Human Omim: 606339 Human SwissProt: Q9Y5F0 Human Unigene: 283803 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
该基因是原粘蛋白β基因簇的成员，是与五号染色体连锁的三个相关基因簇之一。基因簇表现出与B细胞和T细胞受体基因簇相似的异常基因组结构。β-簇包含16个基因和3个假基因，每个编码6个胞外钙黏蛋白结构域和一个胞浆尾部，在钙粘蛋白超家族中与其他基因偏离。胞外结构域以嗜同种方式相互作用，以指定不同的细胞-细胞连接。与α和γ簇不同的是，这些基因的转录只由一个大的外显子组成，不像预期的那样共有3个外显子。这些神经钙黏蛋白样细胞粘附蛋白是完整的质膜蛋白。它们的具体功能尚不清楚，但最有可能在特定细胞-细胞神经连接的建立和功能中起关键作用。[ RefSeq，JUL 2008 ]