FITC标记的补体C8β链抗体
产品名称： FITC标记的补体C8β链抗体
英文名称： Anti-Complement factor 8 beta/FITC
产品编号： HZ-13969R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Complement factor 8 beta/FITC Conjugated antibody
FITC标记的补体C8β链抗体
| 英文名称 | Anti-Complement factor 8 beta/FITC |
| 中文名称 | FITC标记的补体C8β链抗体 |
| 别 名 | C8b; CO8B_HUMAN; Complement component 8 beta polypeptide; Complement component 8 subunit beta; Complement component C8 beta chain. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 细菌及病毒 细胞膜蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 61kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Complement factor 8 beta |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which mediates cell lysis, and it initiates membrane penetration of the complex. This protein mediates the interaction of C8 with the C5b-7 membrane attack complex precursor. In humans deficiency of this protein is associated with increased risk of meningococcal infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] Function: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Subcellular Location: Secreted. Post-translational modifications: N-glycosylated; contains one or two bound glycans. Not O-glycosylated. DISEASE: Defects in C8B are a cause of complement component 8 deficiency type 2 (C8D2) [MIM:120960]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Similarity: Belongs to the complement C6/C7/C8/C9 family. Contains 1 EGF-like domain. Contains 1 LDL-receptor class A domain. Contains 1 MACPF domain. Contains 2 TSP type-1 domains. Database links: Entrez Gene: 732 Human Entrez Gene: 100009385 Rabbit Omim: 120960 Human SwissProt: P07358 Human SwissProt: P98137 Rabbit Unigene: 391835 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码补体成分8（C8）蛋白的三个亚基之一。C8由等摩尔量的α、β和γ亚基组成，它们由三个独立的基因编码。C8是膜攻击复合物的一个组成部分，它介导细胞裂解，并启动复合物的膜穿透。这种蛋白质介导C8与C5B-7膜攻击复合物前体的相互作用。在人类中，这种蛋白质的缺乏与脑膜炎球菌感染的风险增加有关。选择性剪接导致多个转录变体。[ RefSeq 2013军提供]