Nkx2.2,NK2转录样蛋白B抗体

产品编号HZ-11302R
英文名称Nkx2.2
中文名称NK2转录样蛋白B抗体
别 名Homeobox protein NK 2 homolog B; Homeobox protein NK-2 homolog B; Homeobox protein Nkx 2.2; Homeobox protein Nkx-2.2; NK 2 homolog B; NK2 homeobox 2; NK2 transcription factor like protein B; NK2 transcription factor related locus 2; NKX2 2; NKX2-2; NKX22; NKX22_HUMAN; Nkx2b; tinman.
说 明 书0.1ml 0.2ml
研究领域细胞生物 发育生物学 神经生物学 干细胞 转录调节因子 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep,
Nkx2.2,NK2转录样蛋白B抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量30kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Nkx2.2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Nkx2.2,NK2转录样蛋白B抗体PubMedPubMed
产品介绍background:
Members of the NK-2 family of homeodomain proteins are key regulators of growth and development in several tissues, including brain, heart and pancreas. During neural development, sonic hedgehog (Shh) is known to control cell fate and mitogenesis, which is correlated with Shh dose-dependent expression of several genes, including Nkx-2.1, Nkx-2.2 and Nkx-2.9. Specifically, the Nkx-2.2 protein is responsible for directing ventral neuronal patterning in response to graded Shh signaling. In the pancreas, Nkx-2.2 is expressed in a, b and pancreatic polypeptide (PP) cells, but not in d cells. Nkx-2.2 expression is required for differentiation of pancreatic b cells, which produce insulin. Homozygous null mutations of the Nkx-2.2 gene in mice lead to severe hyperglycemia and death shortly after birth, which suggests that Nkx-2.2 may be an important therapeutic target for pancreatic diseases, including diabetes and cancer.

Function:
May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance.

Subunit:
Interacts with OLIG2 (By similarity).

Subcellular Location:
Nucleus.

Similarity:
Belongs to the NK-2 homeobox family.
Contains 1 homeobox DNA-binding domain.

Database links:
Entrez Gene: 4821 Human
Entrez Gene: 18088 Mouse
Entrez Gene: 366214 Rat
Entrez Gene: 531695 Cow
Omim: 604612 Human
SwissProt: O95096 Human
SwissProt: P42586 Mouse
SwissProt: Q90481 Zebrafish
Unigene: 516922 Human
Unigene: 330639 Mouse
Unigene: 32651 Rat

Nkx2.2,NK2转录样蛋白B抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.