FITC标记的精子相关抗原6抗体
产品名称： FITC标记的精子相关抗原6抗体
英文名称： Anti-SPAG6/FITC
产品编号： HZ-12291R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-SPAG6/FITC Conjugated antibody
| FITC标记的精子相关抗原6抗体 |
| 英文名称 | Anti-SPAG6/FITC |
| 中文名称 | FITC标记的精子相关抗原6抗体 |
| 别 名 | PF16; PF16 protein homolog; Protein PF16 homolog; Repro SA 1; Repro-SA-1; SPAG6; SPAG6_HUMAN; Sperm associated antigen 6; Sperm flagellar protein; Sperm-associated antigen 6. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 发育生物学 干细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 55kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SPAG6 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]. Function: Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility. Subunit: Interacts with SPAG16 and SPAG17 (By similarity). Subcellular Location: Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Note=Associated with microtubules. Detected on the sperm flagellum. Tissue Specificity: Highly expressed in testis. Similarity: Contains 8 ARM repeats. Database links: UniProtKB/Swiss-Prot: O75602.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
抗精子抗体与不明原因不孕症的相关性提示这些抗体在阻断受精中的作用。提高免疫性不孕的诊断和治疗，以及鉴定用于定向避孕的蛋白质，取决于相关精子抗原的鉴定和特征。该基因表达的蛋白质是由不育男性的抗精子抗体所识别的。这种蛋白定位于通透的人类精子的尾部，并包含8个连续的犰狳重复序列，一个已知介导蛋白-蛋白相互作用的基序。在小鼠身上的研究表明这种蛋白参与精子鞭毛运动和成熟精子结构完整性的维持。已经发现了几种编码不同亚型的转录本变体。[ RefSeq，DEC 2011 ]提供。