FITC标记的甘丙肽受体2抗体
产品名称： FITC标记的甘丙肽受体2抗体
英文名称： Anti-GALR2/FITC
产品编号： HZ-11527R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-GALR2/FITC Conjugated antibody
FITC标记的甘丙肽受体2抗体
| 产品编号 | bs-11527R-FITC |
| 英文名称 | Anti-GALR2/FITC |
| 中文名称 | FITC标记的甘丙肽受体2抗体 |
| 别 名 | GAL2-R; GAL2R; Galanin receptor 2; Galanin receptor type 2; GALNR2; GALR-2; GALR2; GALR2_HUMAN; MGC125983; MGC125984. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 神经生物学 信号转导 通道蛋白 细胞膜受体 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 42kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GALR2 (51-150aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The 387 amino acid protein galanin receptor-2 (GALR2) protein belongs to a family of G protein-coupled receptors that specifically bind galanin, a neuropeptide distributed throughout the central and peripheral nervous system, the pituitary gland, the gastrointestinal tract and in the endocrine and exocrine pancreas (1-3). GALR2 mRNA is abundant in parvocellular paraventricular nuclei, but in contrast to GALR1, is not expressed in magnocellular neurons or in supraoptic nuclei. Like GALR1 mRNA, GALR2 mRNA is expressed in the POMC neurons, dorsomedial nucleus, arcuate nucleus and in restricted peripheral tissue, with highest mRNA levels in human small intestine (2-5). Galanin-like peptide (GALP) is a putative endogenous ligand for GALR2 (2). Binding of GALP to GALR2 results in increased GTPgS binding to the membrane-bound GALR2 (6). GALR2 is therefore a receptor that mediates important functions of galanin in the hypothalamic-pituitary axis, plays a role in hippocampal and cerebellar function (7) and mediates jejunal contraction (8). Function: Receptor for the hormone galanin and for GALP. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expressed abundantly within the central nervous system in both hypothalamus and hippocampus. In peripheral tissues, the strongest expression was observed in heart, kidney, liver, and small intestine. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: UniProtKB/Swiss-Prot: O43603.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
GalR2受体蛋白（GalR2）是一种G蛋白偶联受体家族，特异结合GalANIN，是一种分布于中枢和外周神经系统、垂体、胃肠道和内分泌的神经肽。胰腺外分泌（1-3）。GalR2mRNA在小室旁核中丰富，但与GALR1相反，在巨核神经元或视上核中不表达。与GALR1 mRNA相似，GalR2 mRNA在POMC神经元、背内侧核、弓状核和限制性外周组织中表达，在小肠中表达最高（2-5）。Galnin样肽（Galp）是GalR2（2）的内源性配体。GALP与GalR2的结合导致GTPGs结合到膜结合的GalR2（6）。因此，GalR2是介导GalANIN在下丘脑-垂体轴中发挥重要作用的受体，在海马和小脑功能中起着重要作用（7），并介导空肠收缩（8）。