FITC标记的慢性粒细胞白血病33抗体
产品名称： FITC标记的慢性粒细胞白血病33抗体
英文名称： Anti-FARSLA/CML33/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-FARSLA/CML33/FITC Conjugated antibody
FITC标记的慢性粒细胞白血病33抗体
| 英文名称 | Anti-FARSLA/CML33/FITC |
| 中文名称 | FITC标记的慢性粒细胞白血病33抗体 |
| 别 名 | CML 33; CML33; FARS; FARSA; FARSL; FRSA; PheHA; Phenylalanine tRNA ligase 1 alpha cytoplasmic; Phenylalanine tRNA ligase alpha chain; Phenylalanine tRNA synthetase alpha subunit; Phenylalanine tRNA synthetase like alpha subunit; Phenylalanyl tRNA synthetase alpha chain; Phenylalanyl tRNA synthetase alpha subunit; Phenylalanyl tRNA synthetase like alpha subunit; PheRS. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 57kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FARSLA/CML33 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Aminoacyl-tRNA synthetases consist of a family of enzymes that catalyze the specific aminoacylation of tRNA by their cognate amino acid in the initial step of ribosome-dependent protein biosynthesis. FARSLA, also known as FRSA, CML33, FARSL or PheHA (phenylalanyl-tRNA synthetase, alpha subunit), is a member of the class-II aminoacyl-tRNA synthetase family and is highly expressed in proliferating cells of bone marrow. FARSLA is a cytoplasmic phenylalanine-tRNA synthetase that functions as a heterodimer consisting of a catalytic alpha-subunit and a regulatory beta-subunit. The alpha-subunit is responsible for forming the amino acid binding pocket, mediating the ATP/aminoacyl adenylate binding, and interacts with the acceptor stem of the tRNA. FARSLA functions in a cell cycle-dependent and differentiation-dependent manner. Function: FARSLA (Phenylalanyl-tRNA synthetase alpha chain) is an aminoacyl-tRNA synthetase. These are a class of enzymes that charge tRNAs with their cognate amino acids. Cytoplasmic phenylalanine-tRNA synthetase is a heterodimer consisting of a catalytic alpha subunit, FARSLA, and a regulatory beta subunit, FARSLB. This protein has been shown to be expressed in a tumor-selective and cell cycle stage- and differentiation-dependent manner, the first member of the tRNA synthetase family shown to exhibit this type of regulated expression. Subcellular Location: Cytoplasmic. Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. Database links: Entrez Gene: 2193 Human Entrez Gene: 66590 Mouse Entrez Gene: 288917 Rat Omim: 602918 Human SwissProt: Q9Y285 Human SwissProt: Q8C0C7 Mouse SwissProt: Q505J8 Rat Unigene: 23111 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
| 氨基酰-tRNA合成酶是一类酶，在核糖体依赖的蛋白质生物合成的初始阶段，它们通过其同源氨基酸催化tRNA的特异性氨基酰化。FARSLA，又称FRSA、CML33、FARSL或PheHA(丙酰-tRNA合成酶，α亚基)，是II类氨基酰-tRNA合成酶家族的成员，在骨髓增生细胞中高度表达。FARSLA是一种胞质丙氨酸-tRNA合成酶，其作为由催化性α亚基和调节性β亚基组成的异二聚体。α亚基负责形成氨基酸结合袋，介导ATP/氨基酰腺苷酸结合，并与tRNA的受体杆相互作用。FARSLA在细胞周期依赖性和分化依赖性中起作用。 | |