FITC标记的肿瘤坏死因子受体1相关死亡域蛋白抗体
产品名称： FITC标记的肿瘤坏死因子受体1相关死亡域蛋白抗体
英文名称： Anti-TRADD/FITC
产品编号： HZ-1202R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-TRADD/FITC Conjugated antibody
FITC标记的肿瘤坏死因子受体1相关死亡域蛋白抗体
| 英文名称 | Anti-TRADD/FITC |
| 中文名称 | FITC标记的肿瘤坏死因子受体1相关死亡域蛋白抗体 |
| 别 名 | TNFR1 associated DEATH domain protein; TNFR1-associated DEATH domain protein; TNFRSF1A associated via death domain; TNFRSF1A-associated via death domain; tradd; TRADD_HUMAN; Tumor necrosis factor receptor type 1 associated DEATH domain protein; Tumor necrosis factor receptor type 1-associated DEATH domain protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 心血管 细胞生物 细胞凋亡 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 34kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from the middle of mouse TRADD |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. Function: Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. Subunit: Interacts with TRIP12. Heterodimer with TNFRSF1A/TNFR1. Interacts with DAB2IP, FADD, HIPK2, KRT14, KRT16, KRT17, KRT18, RIPK1, SQSTM1, TRAF1, TRAF2 and TRPC4AP. Subcellular Location: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Shuttles between the cytoplasm and the nucleus. Tissue Specificity: Found in all examined tissues. Similarity: Contains 1 death domain. Database links: Entrez Gene: 8717 Human Entrez Gene: 71609 Mouse Entrez Gene: 246756 Rat Omim: 603500 Human SwissProt: Q15628 Human SwissProt: Q3U0V2 Mouse Unigene: 460996 Human Unigene: 264255 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. TRADD在凋亡信号传导中起重要作用，近年来多用于研究其在肿瘤中的作用，探讨TRADD在促细胞凋亡和促细胞存活的机制如何控制，将有利于我们了解肿瘤发病机理。 |
TNFRSF1A/TNFR1的适配分子，与活化的TNFRSF1A/TNFR1的细胞质结构域特异性结合，介导其与FADD的相互作用。TRAD的过度表达导致TNF诱导的两种主要反应：凋亡和NF-kAPAB的激活。