FITC标记的去整合素样金属蛋白酶9抗体
产品名称： FITC标记的去整合素样金属蛋白酶9抗体
英文名称： Anti-ADAM9/FITC
产品编号： HZ-20104R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ADAM9/FITC Conjugated antibody
FITC标记的去整合素样金属蛋白酶9抗体
| 英文名称 | Anti-ADAM9/FITC |
| 中文名称 | FITC标记的去整合素样金属蛋白酶9抗体 |
| 别 名 | A disintegrin and metalloproteinase domain 9; A disintegrin and metalloproteinase domain 9; ADAM 9 antibody ADAM metallopeptidase domain 9; Cellular disintegrin related protein; Disintegrin and metalloproteinase domain 9; MCMP; MDC9; Meltrin gamma; Metalloprotease disintegrin cysteine rich protein 9; Mltng; Myeloma cell metalloproteinase; ADAM9_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 信号转导 锌指蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 88kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ADAM9 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq]. Function: Probable zinc protease. May mediate cell-cell or cell-matrix interactions. Isoform 2 displays alpha-secretase activity for APP. [COFACTOR] Binds 1 zinc ion per subunit (Probable). Subunit: Interacts with SH3GL2 and SNX9 through its cytoplasmic tail. Subcellular Location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Tissue Specificity: Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart. DISEASE: Cone-rod dystrophy 9 (CORD9) [MIM:612775]: An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Contains 1 disintegrin domain. Contains 1 EGF-like domain. Contains 1 peptidase M12B domain. Database links: Entrez Gene: 8754 Human Entrez Gene: 11502 Mouse Entrez Gene: 290834 Rat Omim: 602713 Human SwissProt: Q13443 Human SwissProt: Q61072 Mouse Unigene: 591852 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
这个基因编码ADAM（去整合素和金属蛋白酶结构域）家族的成员。该家族的成员是膜锚定蛋白，其结构上与蛇毒解整合素有关，并已牵涉到涉及细胞-细胞和细胞-基质相互作用的各种生物学过程，包括受精、肌肉发育和神经发生。该基因编码的蛋白与含SH3结构域的蛋白相互作用，结合有丝分裂阻滞缺陷的2β蛋白，并且还参与TPA诱导的膜锚定型肝素结合EGF样生长因子的外区脱落。已经鉴定出该基因的几个选择性剪接的转录体变体。[由RefSeq提供]。