FITC标记的突触结合蛋白11抗体
产品名称： FITC标记的突触结合蛋白11抗体
英文名称： Anti-Synaptotagmin XI/FITC
产品编号： HZ-11399R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Synaptotagmin XI/FITC Conjugated antibody
FITC标记的突触结合蛋白11抗体
| 产品编号 | bs-11399R-FITC |
| 英文名称 | Anti-Synaptotagmin XI/FITC |
| 中文名称 | FITC标记的突触结合蛋白11抗体 |
| 别 名 | Synaptotagmin 11; Synaptotagmin 12; Synaptotagmin XI; Synaptotagmin-11; synaptotagmin XII; synaptotagmin-XII; Synaptotagmin11; Synaptotagmin12; Synaptotagmin-11; Synaptotagmin-12; SynaptotagminXI; SYT 11; SYT 12; SYT-11; SYT-12; Syt XI; Syt11; SYT11_HUMAN; SYT12; SytXI; DKFZp781D015; KIAA0080; MGC10881; MGC17226. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 48kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Synaptotagmin XI (51-100aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Synaptotagmins are a large family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles. Synaptotagmin XI, also known as SYT11 (Synaptotagmin-11), is a 431 amino acid protein that localizes to the membrane and is expressed ubiquitously with highest expression in brain and lung. Like other Synaptotagmin proteins, Synaptotagmin XI is involved in the calcium-dependent exocytosis of secretory vesicles and is thought to act as a calcium sensor during vesicular trafficking. Synaptotagmin XI contains two C2 domains through which it can bind either three calcium ions or the zinc-finger protein Parkin (a juvenile Parkinson’s disease gene product), the latter of which causes the polyubiquitination and subsequent degradation of Synaptotagmin XI by the proteasome complex. Defects in the gene encoding Synaptotagmin XI are implicated in a number of neurological disorders, including schizophrenia and Parkinson’s disease. Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Subunit: Homodimer. Can also form heterodimers. Interacts with PARK2. Subcellular Location: Membrane; Single-pass membrane protein. Cell junction, synapse. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Note=In substantia nigra, observed in neuronal cell bodies and neurites. Found in the core of the Lewy bodies in the brain of sporadic Parkinson disease patients. Post-translational modifications: Ubiquitinated and targeted to the proteasome complex for degradation. Similarity: Belongs to the synaptotagmin family. Contains 2 C2 domains. Database links: Entrez Gene: 23208 Human Entrez Gene: 229521 Mouse Entrez Gene: 60568 Rat Omim: 608741 Human SwissProt: Q9BT88 Human SwissProt: Q9R0N3 Mouse SwissProt: O08835 Rat Unigene: 32984 Human Unigene: 379376 Mouse Unigene: 9805 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
突触小体是突触囊泡III型整合膜蛋白的一个大家族，它起着调节胞吐作用和胞吞作用的作用，并参与分泌小泡的神经递质分泌。突触席，也被称为syt11（synaptotagmin-11），是一个431个氨基酸的蛋白，定位于膜和广泛在脑和肺组织表达最高。像其他突触蛋白synaptotagmin席是参与分泌囊泡的钙依赖的胞吐和被认为是在囊泡运输钙传感器。突触席包含两个C2结构域通过它可以绑定是3钙或锌指蛋白Parkin（少年帕金森病基因产物），后者导致的多聚泛素化和随后的突触席被蛋白酶体降解的复杂。在编码蛋白的基因缺陷席有牵连的一些神经系统疾病，包括精神分裂症和帕金森氏病