FITC标记的单链DNA结合蛋白2抗体
产品名称： FITC标记的单链DNA结合蛋白2抗体
英文名称： Anti-OBFC2A/FITC
产品编号： HZ-19562R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-OBFC2A/FITC Conjugated antibody
FITC标记的单链DNA结合蛋白2抗体
| 英文名称 | Anti-OBFC2A/FITC |
| 中文名称 | FITC标记的单链DNA结合蛋白2抗体 |
| 别 名 | FLJ13624; FLJ22833; hSSB2; MGC111163; Nabp1; Nucleic acid-binding protein 1; OBFC2A; Oligonucleotide/oligosaccharide binding fold containing 2A; Oligonucleotide/oligosaccharide binding fold containing protein 2A; Oligonucleotide/oligosaccharide-binding fold-containing protein 2A; Sensor of single strand DNA complex subunit B2; Sensor of single-strand DNA complex subunit B2; Sensor of ssDNA subunit B2; Single stranded DNA binding protein 2; Single-stranded DNA-binding protein 2; SOSB2_HUMAN; SOSS B2; SOSS complex subunit B2; SOSS-B2; SSB2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 结合蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 22kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human OBFC2A |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008] Function: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Subunit: Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1. {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}. Subcellular Location: Nucleus. Localizes to nuclear foci following DNA damage. Similarity: Belongs to the SOSS-B family. SOSS-B2 subfamily. Contains 1 OB DNA-binding domain. Database links: Entrez Gene: 64859 Human Entrez Gene: 109019 Mouse Entrez Gene: 363227 Rat Omim: 612103 Human SwissProt: Q96AH0 Human SwissProt: Q8BGW5 Mouse SwissProt: Q5FVP2 Rat Unigene: 591610 Human Unigene: 196290 Mouse Unigene: 21433 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
单链DNA(ssDNA)-结合蛋白，如OBFC2A，是普遍存在的，对于包括复制、重组和损伤检测和修复在内的各种DNA代谢过程是必不可少的(Richard等人，2008[PubMed 18449195])。