FITC标记的谷氨酸脱羧酶65+谷氨酸脱羧酶67抗体
产品名称： FITC标记的谷氨酸脱羧酶65+谷氨酸脱羧酶67抗体
英文名称： Anti-GAD65 + GAD67/FITC
产品编号： HZ-13263R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GAD65 + GAD67/FITC Conjugated antibody
FITC标记的谷氨酸脱羧酶65+谷氨酸脱羧酶67抗体
| 英文名称 | Anti-GAD65 + GAD67/FITC |
| 中文名称 | FITC标记的谷氨酸脱羧酶65+谷氨酸脱羧酶67抗体 |
| 别 名 | 65 kDa glutamic acid decarboxylase; DCE 2; DCE2; GAD 2; GAD 65; GAD-2; GAD-65;GAD 65, GAD2; Glutamate Decarboxylase 2 (pancreatic islets and brain 65kDa); Glutamate Decarboxylase 2; Glutamate Decarboxylase 65; Glutamate decarboxylase 65 kDa isoform; Glutamic Acid Decarboxylase 2; Glutamic Acid Decarboxylase 65; DCE1_HUMAN; DCE2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 细胞类型标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 65+67kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GAD65 + GAD67 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma aminobutyric acid from L glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin dependent diabetes. This gene may also play a role in the stiff man syndrome. Function: Catalyzes the production of GABA. Subcellular Location: Cytoplasm; cytosol. Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters. Similarity: Belongs to the group II decarboxylase family. Database links: Entrez Gene: 2572 Human Entrez Gene: 14417 Mouse Entrez Gene: 24380 Rat Omim: 138275 Human SwissProt: Q05329 Human SwissProt: Q5VZ29 Human SwissProt: Q5VZ30 Human SwissProt: P48320 Mouse SwissProt: Q548L4 Mouse SwissProt: Q05683 Rat Unigene: 231829 Human Unigene: 4784 Mouse Unigene: 29951 Rat
Entrez Gene: 2571 Human Entrez Gene: 14415 Mouse Entrez Gene: 24379 Rat Omim: 605363 Human SwissProt: Q99259 Human SwissProt: P48318 Mouse SwissProt: P18088 Rat Unigene: 420036 Human Unigene: 272120 Mouse Unigene: 91245 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码多种形式的谷氨酸脱羧酶中的一种，在胰岛素依赖型糖尿病中被鉴定为主要的自身抗原。酶编码负责催化从L-谷氨酸生产γ-氨基丁酸。由于该酶已被鉴定为胰岛素依赖型糖尿病的自身抗体和自身反应性T细胞靶标，因此在人胰腺中已经鉴定出其致病作用。该基因也可能在僵硬人综合征中发挥作用。