FITC标记的G蛋白偶联受体17抗体
产品名称： FITC标记的G蛋白偶联受体17抗体
英文名称： Anti-GPR17/FITC
产品编号： HZ-13521R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GPR17/FITC Conjugated antibody
FITC标记的G蛋白偶联受体17抗体
| 英文名称 | Anti-GPR17/FITC |
| 中文名称 | FITC标记的G蛋白偶联受体17抗体 |
| 别 名 | DKFZp686M18273; G protein coupled receptor 17; G-protein coupled receptor 17; GPR 17; Gpr17; GPR17_HUMAN; P2Y like receptor; P2Y-like receptor; Probable P2Y purinoceptor GPR 17; Probable P2Y purinoceptor GPR17; R12; UDP/CysLT receptor; Uracil nucleotide/cysteinyl leukotriene receptor; GPCR GPR17. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 41kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human G protein coupled receptor 17 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: G protein-coupled receptor 17, GPR17, also known as uracil nucleotide/cysteinyl leukotriene receptor or P2Y-like receptor (P2YL), is a 367 amino acid member of the G-protein coupled receptor 1 family of proteins. While GPR17 is expressed in kidney, heart and umbilical vein endothelial cells, it is expressed in the highest levels in the brain. Upon brain injury, the extracellular concentrations of nucleotides and cysteinyl leukotrienes (CysLTs), two families of endogenous signaling molecules, increase significantly at the site of damage. In some neurons, GPR17, a membrane receptor for uracil nucleotide and CysLTs, is upregulated as well, infiltrating the lesioned area. GPR17 is thought to play a role in mediating neuronal death, remodeling brain circuitries by microglia and initiating remyelination in damaged neurons. Two named isoforms of GPR17 exist as a result of alternative splicing events. Function: Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia. Subcellular Location: Cell membrane. Tissue Specificity: Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 2840 Human Entrez Gene: 574402 Mouse Entrez Gene: 767613 Rat Omim: 603071 Human SwissProt: Q13304 Human SwissProt: Q6NS65 Mouse SwissProt: Q09QM4 Rat Unigene: 46453 Human Unigene: 688940 Human Unigene: 391108 Mouse Unigene: 212749 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
G蛋白偶联受体17，GPR17，也称为尿嘧啶核苷酸/半胱氨酸白三烯受体或P2Y样受体(P2YL)，是G蛋白偶联受体1蛋白家族的367个氨基酸成员。GPR17在肾脏、心脏和脐静脉内皮细胞中表达，在大脑中表达最高。在脑损伤后，核苷酸和半胱氨酸白三烯（CysLT）这两个内源性信号分子家族的细胞外浓度在损伤部位显著增加。在一些神经元中，尿嘧啶核苷酸和CysLT的膜受体GPR17也上调，并浸润受损区域。GPR17被认为在介导神经元死亡、通过小胶质细胞重塑脑电路以及启动受损神经元的再髓鞘化中起作用。两个命名的GPR17异构体存在作为替代剪接事件的结果。