FITC标记的电压门控性钾通道蛋白亚基kv5.1抗体
产品名称： FITC标记的电压门控性钾通道蛋白亚基kv5.1抗体
英文名称： Anti-KCNF1/FITC
产品编号： HZ-12173R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-KCNF1/FITC Conjugated antibody
FITC标记的电压门控性钾通道蛋白亚基kv5.1抗体
| 英文名称 | Anti-KCNF1/FITC |
| 中文名称 | FITC标记的电压门控性钾通道蛋白亚基kv5.1抗体 |
| 别 名 | IK 8; IK8; KCNF 1; KCNF; Kcnf1; KCNF1_HUMAN; kH 1; kH1; KV5.1; Potassium voltage-gated channel subfamily F member 1; MGC33316; Potassium channel KH1; Potassium channel Kv5.1; Potassium voltage gated channel subfamily F member 1; Potassium voltage-gated channel subfamily F member 1; Voltage gated potassium channel subunit Kv5.1; Voltage-gated potassium channel subunit Kv5.1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 神经生物学 信号转导 通道蛋白 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 56kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human KCNF1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: KCNF1 is a multi-pass membrane-bound protein that acts as an ion channel and is generally expressed as a heterotetramer of potassium channeling proteins. Formerly known as kH1, KCNF1 is usually found as a heteromer with three other potassium channel proteins, KCNG3, KV6.3 and KCNV2. As a potassium channel protein, KCNF1 plays a role in regulating apoptosis and proliferation of pulmonary artery smooth muscle (PASM) cells. Bone morphogenetic proteins (BMPs) restrict proliferation and can induce apoptosis in normal human PASM cells and will upregulate expression of KCNF1 in PASM cells in vitro. KCNF1 is expressed in heart, brain, liver, skeletal muscle, kidney and pancreas. Function: Putative voltage-gated potassium channel. Subunit: Heteromultimer with KCNG3, KCNG4 and KCNV2. Interacts with DLG1. Subcellular Location: Membrane. Tissue Specificity: Detected in heart, brain, liver, skeletal muscle, kidney and pancreas. Similarity: Belongs to the potassium channel family. F (TC 1.A.1.2) subfamily. Kv5.1/KCNF1 sub-subfamily. Database links: Entrez Gene: 3754 Human Entrez Gene: 382571 Mouse Omim: 603787 Human SwissProt: Q9H3M0 Human SwissProt: Q7TSH7 Mouse Unigene: 23735 Human Unigene: 40173 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
KCNF1是一种多通道膜结合蛋白，其作为离子通道，通常以钾通道蛋白的异源四聚体表达。以前被称为KH1，KCNF1通常被发现为具有三个其它钾通道蛋白的异构体，KCNG3、Kv63和KCNV2。KCNF1作为一种钾通道蛋白，在调节肺动脉平滑肌（PASM）细胞凋亡和增殖中起重要作用。骨形态发生蛋白（BMPs）在体外可抑制正常人PASM细胞的增殖，诱导其凋亡，上调KCNF1的表达。KCNF1在心脏、脑、肝、骨骼肌、肾脏和胰腺中均有表达。