FITC标记的核酸内切酶8样蛋白2抗体
产品名称： FITC标记的核酸内切酶8样蛋白2抗体
英文名称： Anti-NEIL2/FITC
产品编号： HZ-19193R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-NEIL2/FITC Conjugated antibody
FITC标记的核酸内切酶8样蛋白2抗体
| 英文名称 | Anti-NEIL2/FITC |
| 中文名称 | FITC标记的核酸内切酶8样蛋白2抗体 |
| 别 名 | NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226])[supplied by OMIM, Mar 2008] |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 30, 37kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NEIL2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226])[supplied by OMIM, Mar 2008] Function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Subcellular Location: Nucleus. Tissue Specificity: Detected in testis, skeletal muscle, heart, brain, placenta, lung, pancreas, kidney and liver. Similarity: Belongs to the FPG family. Contains 1 FPG-type zinc finger. Database links: Entrez Gene: 252969 Human Entrez Gene: 382913 Mouse Entrez Gene: 305957 Rat Omim: 608933 Human SwissProt: Q6IE77 Cow SwissProt: Q969S2 Human SwissProt: Q6R2P8 Mouse Unigene: 293818 Human Unigene: 239490 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
NeIL2属于一类与细菌FPG/NEI家族同源的DNA糖基化酶。这些糖基化酶通过裂解被活性氧物种破坏的碱基并通过相关的裂解酶反应引入DNA链断裂，开始了碱基切除修复的第一步(Bandaru等人，2002[PubMed 12509226])[由OMIM提供，2008年3月]