FITC标记的尿皮质素UCN3抗体
产品名称： FITC标记的尿皮质素UCN3抗体
英文名称： Anti-Urocortin 3/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Urocortin 3/FITC Conjugated antibody
FITC标记的尿皮质素UCN3抗体
| 英文名称 | Anti-Urocortin 3/FITC |
| 中文名称 | FITC标记的尿皮质素UCN3抗体 |
| 别 名 | SCP; SPC; Stresscopin; Ucn III; UCN3; UCN3 urocortin 3 stresscopin; UCNIII; Urocortin 3 stresscopin; Urocortin III; UCN3_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 心血管 细胞生物 神经生物学 生长因子和内分泌病 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 4/18kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human UCN3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Urocortin 3 is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. A powerful cytoprotective effect of urocortin peptide administration against ischemia and reperfusion injury has been demonstrated in isolated cardiomyocyte models, as well as in the intact heart both in vitro and in vivo. Function: Urocortin 3 is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. A powerful cytoprotective effect of urocortin peptide administration against ischemia and reperfusion injury has been demonstrated in isolated cardiomyocyte models, as well as in the intact heart both in vitro and in vivo. Subunit: Binds with high affinity to CRF receptors 2-alpha and 2-beta. Subcellular Location: Secreted. Similarity: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. Database links: Entrez Gene: 114131 Human Omim: 605901 Human SwissProt: Q969E3 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
尿皮质醇3是一种Survivin／促肾上腺皮质释放因子/尾加压素I家族的成员。它与促肾上腺皮质释放因子（CRF）基因结构有关，编码产物是CRF 2型受体的内源性配体。在大脑中，它可能是压力对食欲的影响。尽管基因家族相似，但该基因的产物与尾加压素II没有序列相似性。
在分离的心肌细胞模型中，以及在体外和体内的完整心脏中，证明了尿皮质醇肽对缺血再灌注损伤的强有力的细胞保护作用。