FITC标记的胱抑素D/半胱氨酸蛋白酶抑制剂D抗体
产品名称： FITC标记的胱抑素D/半胱氨酸蛋白酶抑制剂D抗体
英文名称： Anti-Cystatin D/FITC
产品编号： HZ-9215R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Cystatin D/FITC Conjugated antibody
FITC标记的胱抑素D/半胱氨酸蛋白酶抑制剂D抗体
| 产品编号 | bs-9215R-FITC |
| 英文名称 | Anti-Cystatin D/FITC |
| 中文名称 | FITC标记的胱抑素D/半胱氨酸蛋白酶抑制剂D抗体 |
| 别 名 | CST 5; CST5; Cystatin 5; Cystatin5; Cystatin-5; CystatinD; Cystatin D; Cysteine proteinase inhibitor; MGC71922; CYTD_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 14kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Cystatin D |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The cystatin superfamily is a well-established family of cysteine protease inhibitors. Cystatins A and B (type 1) are mainly intracellular; cystatins C, D, E/M, F, G, S, SN and SA cystatins are extracellular (type 2); and the kininogens are type 3 cystatins which are intravascular proteins. All true cystatins inhibit cysteine peptidases of the papain family, such as cathepsins, and some also inhibit legumain family enzymes. Cystatin SA, cystatin S and cystatin SN are found primarily in saliva. Cystatin S and SN can also be expressed in tears, urine and seminal fluid. Cystatin C is a related protein which is expressed in brain, thymus, ovary, epididymis and vas deferens. Cystatin D protects against proteinases in the oral cavity, while Cystatin E/M and F moderate the inhibition of cathepsin proteins. The fetuins, part of the cystatin superfamily, are secretable proteins that influence osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors and the response to systemic inflammation. High molecular weight kininogen (Kininogen HC) and low molecular weight kininogen (Kininogen LC) have varied roles, though they both inhibit the thrombin- and plasmin-induced aggregation of thrombocytes. Function: Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B. Subunit: Monomer. Subcellular Location: Secreted Tissue Specificity: Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in parotid gland but not in seminal vesicle, prostate, epididymis, testis, ovary, placenta, thyroid, gastric corpus, small intestine, liver, or gall bladder tissue. Similarity: Belongs to the cystatin family. Database links: Entrez Gene: 1473 Human Omim: 123858 Human SwissProt: P28325 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
半胱氨酸蛋白酶抑制剂超家族是一个成熟的半胱氨酸蛋白酶抑制剂家族。半胱氨酸蛋白酶抑制剂A和B（1型）主要是细胞内的，半胱氨酸蛋白酶抑制剂C、D、E／M、F、G、S、Sn和SA半胱氨酸蛋白酶抑制剂是胞外（2型），而激肽原是3种半胱氨酸蛋白酶抑制剂，是血管内蛋白。所有真正的半胱氨酸蛋白酶抑制剂抑制木瓜蛋白酶家族的半胱氨酸肽酶，如组织蛋白酶，也有一些抑制LeGuMe家族酶。半胱氨酸蛋白酶抑制剂SA、半胱氨酸蛋白酶抑制剂S和半胱氨酸蛋白酶抑制剂SN主要存在于唾液中。胱抑素S和SN也可在泪液、尿液和精液中表达。半胱氨酸蛋白酶抑制剂C是一种在脑、胸腺、卵巢、附睾和输精管中表达的相关蛋白。胱抑素D对口腔内蛋白酶的保护作用，而半胱氨酸蛋白酶抑制剂E／M和F对组织蛋白酶D的抑制作用适中。胎肝素是半胱氨酸蛋白酶抑制剂超家族的一部分，是可影响成骨和骨吸收、调节胰岛素和肝细胞生长因子受体和对全身炎症反应的可分泌蛋白。高分子量激肽原（Kiin原HC）和低分子量激肽原（Kiin原LC）具有不同的作用，但它们都抑制凝血酶和纤溶酶诱导的血小板聚集。