FITC标记的黑色素瘤抗原F蛋白家族1抗体
产品名称： FITC标记的黑色素瘤抗原F蛋白家族1抗体
英文名称： Anti-MAGEF1/FITC
产品编号： HZ-6231R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-MAGEF1/FITC Conjugated antibody
FITC标记的黑色素瘤抗原F蛋白家族1抗体
| 英文名称 | Anti-MAGEF1/FITC |
| 中文名称 | FITC标记的黑色素瘤抗原F蛋白家族1抗体 |
| 别 名 | MAGE F1 antigen; MAGEF 1; Melanoma antigen family F, 1; Melanoma associated antigen F1; MGC19617; MAGF1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 染色质和核信号 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Dog, Pig, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 35kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MAGEF1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: MAGEF1 is a member of the MAGE (melanoma antigen gene) superfamily. Most known members of the MAGE superfamily are expressed in tumors, testis and fetal tissues, which has been described as a cancer/testis or "CT" expression pattern. MAGEF1, however, is expressed in all adult and fetal tissues tested, as well as in many tumor types including ovarian, breast, cervical, melanoma and leukemia. The coding region of MAGE-F1 is contained within a single exon and includes a microsatellite repeat. Several MAGE genes are ubiquitously expressed suggesting a role for MAGE encoded proteins in normal cell physiology. Function: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Subunit: Interacts with LNX1, TRIM27 and NSMCE1. Tissue Specificity: Ubiquitous. Similarity: Contains 1 MAGE domain. Database links: UniProtKB/Swiss-Prot: Q9HAY2.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
MAGEF1是MAGE（黑色素瘤抗原基因）超家族的成员。大多数已知的MAGE超家族成员在肿瘤、睾丸和胎儿组织中表达，其被描述为癌/睾丸或“CT”表达模式。然而，MAGEF1在所有和胎儿组织中表达，以及在许多肿瘤类型中，包括卵巢癌、乳腺癌、宫颈癌、黑色素瘤和白血病。MAGE-F1的编码区包含在单个外显子中，并包含微卫星重复。几种MAGE基因普遍表达，提示MAGE编码蛋白在正常细胞生理学中的作用。