TNRC6B,三核苷酸重复蛋白6B抗体

产品编号HZ-11489R
英文名称TNRC6B
中文名称三核苷酸重复蛋白6B抗体
别 名KIAA1093; TNRC 6B; Trinucleotide repeat containing 6B; Trinucleotide repeat containing gene 6B protein; TNR6B_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 神经生物学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Sheep,
TNRC6B,三核苷酸重复蛋白6B抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量194kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human TNRC6B (25-70aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
TNRC6B,三核苷酸重复蛋白6B抗体PubMedPubMed
产品介绍background:
TNRC6B is a 1,723 amino acid protein that exists as two alternatively spliced isoforms and is thought to be involved in mRNA cleavage events. Expressed ubiquitously, TNRC6B contains one glycine/tryptophan (GW)-rich N-terminal domain, one central glutamine-rich region and one C-terminal RNA recognition motif and is encoded by a gene that maps to human chromosome 22. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia. Additionally, translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia Chromosome and the subsequent production of the novel fusion protein BCR-Abl, a potent cell proliferation activator found in several types of leukemias.

Function:
TNRC6B belongs to the GW182 family. It contains one RRM (RNA recognition motif) domain. TNRC6B plays a role in RNA mediated gene silencing by both micro RNAs (miRNAs) and short interfering RNAs (siRNAs). It is required for miRNA dependent translational repression and siRNA dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. There are three named isoforms.

Subunit:
Interacts with EIF2C1/AGO1, EIF2C2/AGO2, EIF2C3/AGO3 and EIF2C4/AGO4.

Subcellular Location:
Cytoplasm, P-body. Mammalian P-bodies are also known as GW bodies, GWBs.

TNRC6B,三核苷酸重复蛋白6B抗体Similarity:
Belongs to the GW182 family.
Contains 1 RRM (RNA recognition motif) domain.

Database links:
UniProtKB/Swiss-Prot: Q9UPQ9.4

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.