FITC标记的血清类粘蛋白1样蛋白1+2+3抗体
产品名称： FITC标记的血清类粘蛋白1样蛋白1+2+3抗体
英文名称： Anti-ORMDL1 + ORMDL2 + ORMDL3/FITC
产品编号： HZ-18035R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ORMDL1 + ORMDL2 + ORMDL3/FITC Conjugated antibody
FITC标记的血清类粘蛋白1样蛋白1+2+3抗体
| 英文名称 | Anti-ORMDL1 + ORMDL2 + ORMDL3/FITC |
| 中文名称 | FITC标记的血清类粘蛋白1样蛋白1+2+3抗体 |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Cow, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 17kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ORMDL1 + ORMDL2 + ORMDL3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4°C. |
| 产品介绍 | background: The ORMDL (ORM1-like) family of proteins consist of ORMDL1, ORMDL2 and ORMDL3; all of which are human homologs of the S. cerevisiae ORM1 protein. Localized to the membrane of the endoplasmic reticulum, ORMDLs are multi-pass membrane proteins that are implicated in ?secretase (BACE) function, as well as expression of Presenilin (PSI), a protein involved in Alzheimer抯 disease (AD). ORMDL1 (ORM1-like protein 1), also known as Adoplin-1, is a widely expressed 153 amino acid member of the ORMDL family. Expression of ORMDL1 is down-regulated in PSI mutations, suggesting a possible role as a therapeutic target for AD. ORMDL2 (ORM1-like protein 2), also known as Adoplin-2, and ORMDL3 (ORM1-like protein 3) are expressed in tissues such as heart, brain, lung, liver and kidney. ORMDL3 exists as two isoforms due to alternative splicing events and may be a determinant of susceptibility to childhood asthma Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
ORMDL(ORM1-like)蛋白家族由ORMDL1、ORMDL2和ORMDL3组成，它们都是酿酒酵母ORM1蛋白的人类同源物。定位于内质网的膜，ORDLs是多通道膜蛋白，牵连在？分泌酶（BACE）功能，以及早老素（PSI）的表达，是阿尔茨海默病（AD）中的一种蛋白。OrdL1（ORM1样蛋白1），也称为Adulin -1，是ORMDL家族广泛表达的153氨基酸成员。在PSI突变中，ORMDL1的表达下调，表明ORMDL2(ORM1-like protein 2，也称为Adoplin-2)和ORMDL3(ORM1-like protein 3)可能作为AD的治疗靶点，在心脏、脑、肺、肝脏和肾脏等组织中表达。ORDL3由于选择性剪接事件而作为两种亚型存在，可能是儿童哮*易感性的决定因素。