FITC标记的膜相关环指蛋白8抗体
产品名称： FITC标记的膜相关环指蛋白8抗体
英文名称： Anti-MARCH8/FITC
产品编号： HZ-9342R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-MARCH8/FITC Conjugated antibody
FITC标记的膜相关环指蛋白8抗体
| 产品编号 | bs-9342R-FITC |
| 英文名称 | Anti-MARCH8/FITC |
| 中文名称 | FITC标记的膜相关环指蛋白8抗体 |
| 别 名 | c MIR; c-MIR; Cellular modulator of immune recognition; E3 ubiquitin protein ligase MARCH8; E3 ubiquitin-protein ligase MARCH8; MARCH 8; MARCH VIII; MARCH-VIII; MARCH8; MARH8_HUMAN; Membrane associated RING CH protein VIII; Membrane associated ring finger (C3HC4) 8; Membrane associated RING finger protein 8; Membrane-associated RING finger protein 8; Membrane-associated RING-CH protein VIII; MIR; RING finger protein 178; RNF178. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 33kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MARCH8 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. MARCH8 (membrane-associated ring finger (C3HC4) 8), also known as MIR or RNF178 (RING finger protein 178), is a 291 amino acid multi-pass membrane protein that localizes to vesicle membranes and contains one RING-CH-type zinc finger. Expressed in a variety of tissues, including immature dendritic cells, MARCH8 functions as an E3 ubiquitin ligase that is thought to regulate immune responses by promoting the ubiquitination and subsequent degradation of target proteins, such as B7-2 and CD71. Function: E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS. Subunit: Interacts with CD86. Subcellular Location: Cytoplasmic vesicle membrane. Lysosome membrane. Early endosome membrane. Tissue Specificity: Broadly expressed. Present in immature dendritic cells (at protein level). Similarity: Contains 1 RING-CH-type zinc finger. Database links: Entrez Gene: 220972 Human Entrez Gene: 71779 Mouse Entrez Gene: 312656 Rat SwissProt: Q5T0T0 Human SwissProt: Q9DBD2 Mouse Unigene: 499489 Human Unigene: 27064 Mouse Unigene: 48069 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
环型锌指基序存在于许多病毒和真核蛋白质中，并且由能够结合两个锌原子的保守的富含半胱氨酸的结构域构成。含有保守结构域的蛋白质一般参与蛋白质降解的泛素化途径。MARCH8（膜相关环指（C3HC4）8），也称为MIR或RNF178（环指蛋白178），是一种291氨基酸多膜蛋白，定位于囊泡膜并含有一环CH型锌指。在多种组织中表达，包括未成熟树突状细胞，MARCH8作为E3泛素连接酶发挥作用，被认为通过促进靶蛋白如B7-2和CD71的泛素化和随后的降解来调节免疫应答。