DND1,DND1蛋白抗体

产品编号HZ-14397R
英文名称DND1
中文名称DND1蛋白抗体
别 名Dead end homolog 1 (zebrafish); Dead end protein; Dead end protein homolog 1; dnd1; DND1_HUMAN; MGC34750; RBMS4; RNA binding motif single stranded interacting protein 4; RNA-binding motif; single-stranded-interacting protein 4; Ter.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 发育生物学 干细胞 结合蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
DND1,DND1蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量39kDa
细胞定位细胞核 细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DND1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DND1,DND1蛋白抗体PubMedPubMed
产品介绍background:
This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on the long arm of chromosome 17. [provided by RefSeq, Dec 2010]

Function:
RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration.

Subcellular Location:
Nucleus. Cytoplasm. Perinuclear germ granules, also called germ plasm or chromatoid body. Colocalizes in perinuclear sites with APOBEC3.

Similarity:
Contains 2 RRM (RNA recognition motif) domains.

Gene ID:
373863

Database links:
Entrez Gene: 373863 Human
Entrez Gene: 213236 Mouse
Entrez Gene: 679841 Rat
Omim: 609385 Human
SwissProt: Q8IYX4 Human
SwissProt: Q6VY05 Mouse
Unigene: 591262 Human
Unigene: 234464 Mouse

DND1,DND1蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.