MDM2/CEN12p FISH Probe
产品名称： MDM2/CEN12p FISH Probe
英文名称： MDM2/CEN12p FISH Probe
产品编号： FG0020
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Labeled FISH probes for identification of gene amplification using Fluoresecent In Situ Hybridization Technique. (Technology)
- Storage Instruction:
- Store at 4°C in the dark.
- Quality Control Testing:
- Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
- Supplied Product:
- DAPI Counterstain (1500 ng/mL ) 250 uL
- Note:
Hybridization position of the probes on the chromosome.-
- Probe 1:
Size:
Fluorophore:
Location: - MDM2
Approximately 270kb
Texas Red
12q14.3-q15
- Probe 2:
Size:
Fluorophore:
Location: - CEN12p
Approximately 530kb
FITC
12p11.22
- Probe Gap:
- The gap between two probes is approximately 38,700 kb.
- Origin:
- Human
- Source:
- Genomic DNA
- Regulation Status:
- For research use only (RUO)
- Applications
- Fluorescent In Situ Hybridization (Cell)
- Protocol Download
- Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
enlarge this image- Human angiosarcoma (FFPE) stained with MDM2/CEN12p FISH Probe. Human angiosarcoma showed MDM2 gene amplification
- Protocol Download
- Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
enlarge this image- Human hepatocellular carcinoma (FFPE) stained with MDM2/CEN12p FISH Probe. Human hepatocellular carcinoma showed no MDM2 gene amplification.
- Protocol Download
- Entrez GeneID:
- 4193
- Gene Name:
- MDM2
- Gene Alias:
- HDMX,MGC71221,hdm2
- Gene Description:
- Mdm2 p53 binding protein homolog (mouse)
- Omim ID:
- 164785
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq
- Other Designations:
- Mdm2, transformed 3T3 cell double minute 2, p53 binding protein,double minute 2, human homolog of; p53-binding protein,mouse double minute 2 homolog,p53-binding protein MDM2,ubiquitin-protein ligase E3 Mdm2
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