FITC标记的核纤层蛋白B2抗体
产品名称： FITC标记的核纤层蛋白B2抗体
英文名称： Anti-Lamin B2/FITC
产品编号： HZ-11132R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-Lamin B2/FITC Conjugated antibody
FITC标记的核纤层蛋白B2抗体
| 产品编号 | bs-11132R-FITC |
| 英文名称 | Anti-Lamin B2/FITC |
| 中文名称 | FITC标记的核纤层蛋白B2抗体 |
| 别 名 | Alternative namesLAMB 2; LAMB2; Lamin-B2; LMN 2; LMN B2; LMN2; LMNB 2; LMNB2; LMNB2_HUMAN; MGC2721. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 细胞骨架 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 68kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Lamin B2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: A unique family of Cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, termed CED-3/ICE, functions as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Nuclear lamins are critical to maintaining the integrity of the nuclear envelope and cellular morphology as components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations. Nuclear Lamin B is fragmented as a consequence of apoptosis by an unidentified member of the ICE family. Function: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Subunit: Interacts with TMEM43 (By similarity). Subcellular Location: Nucleus inner membrane; Lipid-anchor; Nucleoplasmic side. Post-translational modifications: B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations. DISEASE: Defects in LMNB2 are a cause of partial acquired lipodystrophy (APLD) [MIM:608709]. A rare childhood disease characterized by loss of subcutaneous fat from the face and trunk. Fat deposition on the pelvic girdle and lower limbs is normal or excessive. Most frequently, onset between 5 and 15 years of age. Most affected subjects are females and some show no other abnormality, but many develop glomerulonephritis, diabetes mellitus, hyperlipidemia, and complement deficiency. Mental retardation in some cases. APLD is a sporadic disorder of unknown etiology. Similarity: Belongs to the intermediate filament family. Database links: Entrez Gene: 84823 Human Entrez Gene: 16907 Mouse Entrez Gene: 299625 Rat Omim: 150341 Human SwissProt: Q03252 Human SwissProt: P21619 Mouse Unigene: 728836 Human Unigene: 7362 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
已经描述了一种独特的半胱氨酸蛋白酶家族，其序列、结构和底物特异性与任何先前描述的蛋白酶家族不同。这个家族，被称为CEDE3/ICE，作为凋亡机制的关键组分，并作用于破坏对细胞寿命至关重要的特定靶蛋白。核纤层蛋白是维持核包膜和细胞形态完整性的关键，是核层的组成部分，是核膜的核质侧上的纤维层，被认为是提供核包膜的框架，也可能是间期。CT染色。B型层粘连蛋白经过一系列修饰，如法尼酯化和磷酸化。膜蛋白磷酸化的增加发生在包膜崩解之前，并且可能在调节层粘连蛋白的作用中起作用。核Lamin B是由一个未确认的ICE家族成员的细胞凋亡所分裂的。