FITC标记的腺苷单磷酸活化蛋白激酶β2抗体
产品名称： FITC标记的腺苷单磷酸活化蛋白激酶β2抗体
英文名称： Anti-AMPK beta 2/FITC
产品编号： HZ-3967R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-AMPK beta 2/FITC Conjugated antibody
FITC标记的腺苷单磷酸活化蛋白激酶β2抗体
| 英文名称 | Anti-AMPK beta 2/FITC |
| 中文名称 | FITC标记的腺苷单磷酸活化蛋白激酶β2抗体 |
| 别 名 | AMP activated protein kinase beta 2 non catalytic subunit; AMPK beta 2; AMPK beta 2 chain; PRKAB 2; Protein kinase AMP activated beta 2 non catalytic subunit; AAKB2_HUMAN; AMPK b2; AMPK-b2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 30kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human AMPK beta 2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: PRKAB2 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status and plays a role in protecting cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase (ACC). It also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase (HMGCR) and hormone-sensitive lipase. PRKAB2 may be a positive regulator of AMPK activity. Function: AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone-sensitive lipase. This is a regulatory subunit, may be a positive regulator of AMPK activity. It may also serve as an adapter molecule for the catalytic alpha-subunit. Post-translational modifications: Phosphorylated when associated with the catalytic subunit. Similarity: Belongs to the 5'-AMP-activated protein kinase beta subunit family. Database links: Entrez Gene: 5565 Human Entrez Gene: 108097 Mouse Entrez Gene: 64562 Rat Omim: 602741 Human SwissProt: O43741 Human SwissProt: Q6PAM0 Mouse SwissProt: Q9QZH4 Rat Unigene: 50732 Human Unigene: 31175 Mouse Unigene: 207202 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
PRKAB2是AMP活化蛋白激酶（AMPK）的调节亚基。AMPK是由α催化亚基和非催化β和γ亚基组成的异三聚体。AMPK是一种重要的能量传感酶，监测细胞能量状态，并通过切断ATP消耗的生物合成途径发挥保护细胞免于引起ATP耗竭的应激作用。AMPK通过acetyl CoA carboxylase（ACC）磷酸化来调控脂肪酸合成。它还通过磷酸化和失活hydroxymethylglutaryl CoA reductase（HMGCR）和激素敏感脂肪酶调节胆固醇合成。PRKAB2可能是AMPK活性的正调控因子。