RIMS3,神经元突触膜胞外分泌调节蛋白3抗体

产品编号HZ-11359R
英文名称RIMS3
中文名称神经元突触膜胞外分泌调节蛋白3抗体
别 名NIM 3; NIM3; Rab 3 interacting molecule 3; Regulating synaptic membrane exocytosis 3; Regulating synaptic membrane exocytosis protein 3; RIMS 3; RIMS-3; RIM 3; RIM3; RIM3 gamma; RIMS3; RIMS3_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 细胞类型标志物
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Zebrafish,
RIMS3,神经元突触膜胞外分泌调节蛋白3抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量33kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human RIMS3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
RIMS3,神经元突触膜胞外分泌调节蛋白3抗体PubMedPubMed
产品介绍background:
Rab 3, a neural/neuroendocrine-specific member of the Rab family, is involved in Ca2+-regulated exocytosis and functions in an inhibitory capacity, controlling the recruitment and pooling of secretory vesicles at the plasma membrane. The Rim (Rab 3 interacting molecule) family of proteins (Rim1, Rim2, Rim3 and Rim4) are multidomain adaptors that regulate Rab 3 activity and sub-sequent neurotransmitter release. Rim3, also known as RIMS3 (regulating synaptic membrane exocytosis 3) or NIM3, is a 308 amino acid member of the Rim family. Localized to the synapse and to cell junctions, Rim3 contains one C2 domain and is thought to play an important role in the regulation of synaptic membrane exocytosis. Rim3, a protein that may be phosphorylated upon DNA damage, is expressed throughout the body with highest levels present in brain tissue.

Function:
RIMS3 belongs to a family of synaptic proteins that are essential for normal neurotransmitter release. It localizes primarily to neuronal dendrites and the postsynaptic densities, indicating that it may contribute to synapse transmission and plasticity.

Subunit:
Binds PPFIA3 (By similarity). Does not bind RAB3.

Subcellular Location:
Cell junction, synapse.

RIMS3,神经元突触膜胞外分泌调节蛋白3抗体Similarity:
Contains 1 C2 domain.

Database links:
UniProtKB/Swiss-Prot: Q9UJD0.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.