FITC标记的Centaurin α1抗体
产品名称： FITC标记的Centaurin α1抗体
英文名称： Anti-Centaurin alpha 1/FITC
产品编号： HZ-11543R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Centaurin alpha 1/FITC Conjugated antibody
FITC标记的Centaurin α1抗体
| 产品编号 | bs-11543R-FITC |
| 英文名称 | Anti-Centaurin alpha 1/FITC |
| 中文名称 | FITC标记的Centaurin α1抗体 |
| 别 名 | ArfGAP with dual PH domains 1; CENTA 1; CENTA1; Centaurin alpha; GCS1L; IP4/PIP3 binding protein; p42IP4; Putative MAPK activating protein PM25; ADAP1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 43kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Centaurin alpha 1 (101-200aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: ADP-ribosylation factor (ARF) family of small GTP-binding proteins are involved in vesicular transport regulation and in controlling cytoskeletal organization and cell adhesion. These proteins are best characterized as regulators of membrane traffic. The Centaurin GTPase-activating protein family comprise a subset of ARF regulatory molecules that transduce PI 3-kinase activation into coordinated control of Arf-dependent pathways. This family includes ASAP1, ACAP1, ACAP2, AGAP1, ARAP1, ARAP2, Centaurin a1 and Centaurin g3. The Centaurin a1 protein is a high affinity PtdIns(3,4,5)P3 binding protein enriched in brain. By acting as a GTPase activating protein for ADP ribosylation factor 6 (ARF6), Centaurin a1 is able to switch off ARF6 and inhibit its ability to mediate b2-adrenoceptor internalization and negatively regulate ARF6 activity by functioning as an in vivo PIP3 dependent ARF6 GAP. Function: The centaurin alpha 1 protein is a high affinity PtdIns(3,4,5)P3 binding protein enriched in brain. By acting as a GTPase activating protein for ADP ribosylation factor 6 (ARF6), centaurin alpha 1 is able to switch off ARF6 and inhibit its ability to mediate beta 2 adrenoceptor internalization and negatively regulates ARF6 activity by functioning as an in vivo PIP3 dependent ARF6 GAP. Subunit: Interacts with PRKCA, PRKCI and PRKCZ. Interacts with the N-terminal region of PRKD1. Subcellular Location: Cellular localizationCytoplasmic, Nuclear and Plasma membrane Tissue Specificity: Expressed at highest levels in brain and at lower levels in peripheral blood leukocytes. Post-translational modifications: Phosphorylated by PRKCA, PRKCI, PRKCZ and PRKD1 in vitro. Similarity: Contains 1 Arf-GAP domain. Contains 2 PH domains. Database links: UniProtKB/Swiss-Prot: O75689.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
ADP核糖基化因子（ARF）家族的小GTP结合蛋白参与囊泡运输调控和控制细胞骨架组织和细胞粘附。这些蛋白质的最佳特征是膜交通的调节器。半人马豆素GTP酶激活蛋白家族包括一个ARF调节分子的子集，其将PI 3-激酶激活转导成ARF依赖性通路的协调控制。该家族包括ASAP1、ACAP1、ACAP2、AGAP1、ARAP1、ARAP2、矢车菊素A1和矢车菊素G3。矢车菊素A1蛋白是一种高亲和力的PtdIns（3，4，5）P3结合蛋白，富含脑组织。通过作为ADP-核糖基化因子6（ARF6）的GTPASE激活蛋白，矢车菊素A1能够切断ARF6并抑制其介导B2肾上腺素受体内化的能力，并通过体内PIP3依赖的ARF6间隙发挥负调节ARF6活性。