FITC标记的LIM同源框蛋白1抗体
产品名称： FITC标记的LIM同源框蛋白1抗体
英文名称： Anti-LIM1/FITC
产品编号： HZ-18271R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-LIM1/FITC Conjugated antibody
FITC标记的LIM同源框蛋白1抗体
| 英文名称 | Anti-LIM1/FITC |
| 中文名称 | FITC标记的LIM同源框蛋白1抗体 |
| 别 名 | hLim-1; Homeo box protein Lim 1; Homeo box protein Lim1; Homeobox protein Lim 1; Homeobox protein Lim-1; Homeobox protein Lim1; LHX 1; LHX1; LHX1_HUMAN; LIM 1; LIM homeo box 1; LIM homeo box protein 1; LIM homeobox 1; LIM homeobox protein 1; LIM-1; LIM/homeobox protein Lhx 1; LIM/homeobox protein Lhx1; MGC126723; MGC138141. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 发育生物学 染色质和核信号 信号转导 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Chimpanzee, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 45kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LIM1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis. Subcellular Location: Nucleus. Tissue Specificity: Expressed in the brain, thymus, and tonsils. Expressed in samples from patients with chronic myeloid leukemia (CML) and in 58% of acute myeloid leukemia (AML) cell lines. Similarity: Contains 1 homeobox DNA-binding domain. Contains 2 LIM zinc-binding domains. Database links: Entrez Gene: 454600 Chimpanzee Entrez Gene: 3975 Human Entrez Gene: 16869 Mouse Entrez Gene: 257634 Rat Omim: 601999 Human SwissProt: Q5IS44 Chimpanzee SwissProt: P48742 Human SwissProt: P63006 Mouse SwissProt: P63007 Rat Unigene: 443727 Human Unigene: 4965 Mouse Unigene: 127825 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
大约有40个已知的真核LIM蛋白，因此命名为它们包含的LIM结构域。LIM结构域是含有2个锌指的高度保守的富含半胱氨酸的结构。虽然锌指通常通过结合DNA或RNA发挥作用，但LIM基序可能介导蛋白质-蛋白质相互作用。LIM激酶-1和LIM激酶-2属于一个具有2个N-末端LIM基序和C-末端蛋白激酶结构域的独特组合的小亚家族。这个基因编码的蛋白质被ROCK磷酸化和激活，ROCK是Rho的下游效应子，而编码的蛋白质反过来磷酸化辅丝蛋白，抑制其肌动蛋白的解聚活性。据认为，这种途径有助于Rho诱导的肌动蛋白细胞骨架重组。已经发现至少三个编码不同亚型的转录变体。[ RefSeq，JUL 2008 ]