FITC标记的促血管平滑肌细胞分化因子抗体
产品名称： FITC标记的促血管平滑肌细胞分化因子抗体
英文名称： Anti-Myocardin/FITC
产品编号： HZ-9472R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Myocardin/FITC Conjugated antibody
FITC标记的促血管平滑肌细胞分化因子抗体
| 产品编号 | bs-9472R-FITC |
| 英文名称 | Anti-Myocardin/FITC |
| 中文名称 | FITC标记的促血管平滑肌细胞分化因子抗体 |
| 别 名 | MYCD; MYCD_HUMAN; Myocardin; Myocd. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 免疫学 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 103kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Myocardin |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Transcriptional factor that uses the canonical single or multiple CArG boxes DNA sequence. Binds CArG boxes only in the presence of serum response factor (SRF). Acts as a cofactor of SRF and modulates SRF-target genes. Regulates the expression of a set of cardiac and smooth muscle-specific genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage. Function: Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis). Subunit: Homodimer. Interacts with SRF, its association does not depend on specific DNA sequences for ternary complex formation. Interacts with MLLT7/FOXO4. Interacts (via C-terminal) with EP300 (via the CREB-binding domain). Interacts with HDAC4 and HDAC5 (By similarity). Interacts with MEF2C. Subcellular Location: Nucleus. Tissue Specificity: Expressed in heart, aorta, and in smooth muscle cell-containing tissues: stomach, bladder, small intestine, colon, lung, placenta and uterus. Very faint expression in prostate and skeletal muscle. Post-translational modifications: Phosphorylation regulates negatively the intrinsic myocardin transcriptional activity. Similarity: Contains 3 RPEL repeats. Contains 1 SAP domain. Database links: Entrez Gene: 93649 Human Entrez Gene: 214384 Mouse Entrez Gene: 396571 Pig Entrez Gene: 246297 Rat Omim: 606127 Human SwissProt: Q8IZQ8 Human SwissProt: Q8VIM5 Mouse SwissProt: Q8R5I7 Rat Unigene: 567641 Human Unigene: 32257 Mouse Unigene: 163103 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
转录因子使用标准的单个或多个CARG盒DNA序列。仅在存在血清反应因子（SRF）的情况下结合CARG盒。作为SRF的辅因子，调节SRF靶基因。调节一组心脏和平滑肌特异基因的表达。在心脏发生和分化的平滑肌细胞谱系中起着至关重要的作用。