GIOT1,锌指蛋白461抗体

产品编号HZ-11406R
英文名称GIOT1
中文名称锌指蛋白461抗体
别 名GIOT-1; GIOT 1; Gonadotropin inducible ovary transcription repressor 1; Gonadotropin inducible transcription repressor 1; Gonadotropin-inducible ovary transcription repressor 1; Zinc finger protein 461; ZN461_HUMAN; ZNF461.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导 生长因子和激素 转录调节因子 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human,
GIOT1,锌指蛋白461抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量66kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human GIOT1/ZNF461 (191-240aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
GIOT1,锌指蛋白461抗体PubMedPubMed
产品介绍background:
GIOT-1 is a 563 amino acid protein belonging to the Krüppel C2H2-type zinc-finger protein family. Localized to the nucleus, GIOT-1 is widely expressed in tissues, with highest levels in liver, kidney, small intestine, pancreas and thymus. GIOT-1 contains 12 C2H2-type zinc fincers and one KRAB domain. Because the KRAB domain functions as a transcriptional repressor when attached to the template DNA, GIOT-1 is thought to be involved in transcriptional regulation. The gene encoding GIOT-1 is localized to chromosome 19q13.12 and two isoforms of GIOT-1 exist as a result of alternative splicing events.

Function:
May be involved in transcriptional regulation.

Subcellular Location:
Nucleus.

Tissue Specificity:
Widely expressed, with highest levels in liver, kidney, pancreas, thymus, and small intestine.

Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 12 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Database links:
Entrez Gene: 92283 Human
Omim: 608640 Human
SwissProt: Q8TAF7 Human
Unigene: 590972 Human

GIOT1,锌指蛋白461抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.