FITC标记的信号转导衔接蛋白1抗体
产品名称： FITC标记的信号转导衔接蛋白1抗体
英文名称： Anti-STAM/FITC
产品编号： HZ-7878R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-STAM/FITC Conjugated antibody
FITC标记的信号转导衔接蛋白1抗体
| 英文名称 | Anti-STAM/FITC |
| 中文名称 | FITC标记的信号转导衔接蛋白1抗体 |
| 别 名 | Signal transducing adapter molecule 1; Signal transducing adapter molecule 2; Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1; Signal transducing adaptor molecule; STAM 1; STAM-2; STAM1; Stam2; STAM2_HUMAN; DKFZp686J2352; Hrs-binding protein; HSE1 homolog; OTTHUMP00000019237. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 细胞周期蛋白 细胞分化 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 59kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human STAM |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). Subunit: Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS. Probably part of a complex at least composed of HSG, STAM and EPS15. Interacts with STAMBP/AMSH. Interacts with PDGFRB. Subcellular Location: Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Tissue Specificity: Ubiquitously expressed. Post-translational modifications: Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF. Similarity: Belongs to the STAM family. Contains 1 ITAM domain. Contains 1 SH3 domain. Contains 1 UIM (ubiquitin-interacting motif) repeat. Contains 1 VHS domain. Database links: Entrez Gene: 10254 Human Entrez Gene: 8027 Human Entrez Gene: 20844 Mouse Entrez Gene: 56324 Mouse Entrez Gene: 311030 Rat Omim: 601899 Human SwissProt: O75886 Human SwissProt: Q92783 Human SwissProt: O88811 Mouse SwissProt: P70297 Mouse SwissProt: Q5XHY7 Rat Unigene: 17200 Human Unigene: 263639 Mouse Unigene: 161793 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
涉及细胞因子和细胞因子介导的细胞内信号转导。在IL-2和GM CSL刺激下，它在导致DNA合成和MYC诱导的信号转导中起作用。也可能在T细胞发育中发挥作用。与HGS（ESCRT-0复合物）复合时，通过多泡体（MVBS）参与受体酪氨酸激酶的下调。ESCRT-0复合物结合泛素，并作为识别泛素化受体的分选机制，并将它们转移到进一步顺序的溶酶体分拣/转运过程中。