FITC标记的NOGO相互作用线粒体蛋白1抗体
产品名称： FITC标记的NOGO相互作用线粒体蛋白1抗体
英文名称： Anti-NIMP/RTN4IP1/FITC
产品编号： HZ-8334R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-NIMP/RTN4IP1/FITC Conjugated antibody
FITC标记的NOGO相互作用线粒体蛋白1抗体
| 产品编号 | bs-8334R-FITC |
| 英文名称 | Anti-NIMP/RTN4IP1/FITC |
| 中文名称 | FITC标记的NOGO相互作用线粒体蛋白1抗体 |
| 别 名 | mitochondrial; NIMP; NOGO interacting mitochondrial protein; NOGO-interacting mitochondrial protein; Reticulon 4 interacting protein 1; Reticulon 4 interacting protein 1, mitochondrial; Reticulon-4-interacting protein 1; RT4I1_HUMAN; Rtn4ip1; NIMP/RTN4IP1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 神经生物学 信号转导 线粒体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 39kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NIMP/RTN4IP1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Appears to be a potent inhibitor of regeneration following spinal cord injury.Nogo is an oligodendrocyte-specific member of the Reticulon family and is a component of CNS white matter that inhibits axon outgrowth, induces collapse of growth cones of chick dorsal root ganglion cells, and inhibits the spreading of 3T3 fibroblasts. Nogo is expressed by oligodendrocytes but not by Schwann cells, and associates primarily with the endoplasmic reticulum. Nogo exists in three different splice forms, Nogo-A, -B and -C. NIMP (NOGO-interacting mitochondrial protein), also known as RTN4IP1 (Reticulon-4-interacting protein 1), is a 396 amino acid mitochondrial protein that contains a C-terminal oxidoreductaselike domain and numerous sites for phosphorylation. NIMP is expressed in mitochondrial-rich tissue such as kidney, heart, skeletal muscle and specific regions within the nervous system. Through interaction with Nogo, it is likely that NIMP plays a role in Nogo-induced inhibition of neurite growth. There are three isoforms of NIMP that are produced as a result of alternative splicing events. Function: Appears to be a potent inhibitor of regeneration following spinal cord injury. Subunit: Interacts with RTN4, UQCRC1 and UQCRC2 (By similarity). Subcellular Location: Mitochondrion. Tissue Specificity: Widely expressed in mitochondria-enriched tissues. Found in heart, muscle, kidney, liver, brain and placenta. Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. Database links: Entrez Gene: 506626 Cow Entrez Gene: 84816 Human Entrez Gene: 170728 Mouse Entrez Gene: 309912 Rat Omim: 610502 Human SwissProt: Q0VC50 Cow SwissProt: Q8WWV3 Human SwissProt: Q924D0 Mouse Unigene: 155839 Human Unigene: 390253 Mouse Unigene: 220185 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
NoGo是脊髓损伤后的一种少突胶质细胞特异性成员，是中枢神经系统白质的一个组成部分，抑制轴突的生长，诱导鸡背根神经节细胞的生长锥的塌陷，并抑制Th细胞的生长。3T3成纤维细胞的E分布。NOGO通过少突胶质细胞表达，但不由雪旺细胞表达，主要与内质网相关联。NoGO以三种不同的剪接形式存在，NoGo-A、-B和-C. NIMP（NoGo相互作用线粒体蛋白），又称RTN4IP1（ReGeReN-4-相互作用蛋白1），是含有C-末端氧化还原酶结构域和大量磷酸化位点的396氨基酸线粒体蛋白。tion. NIMP在线粒体丰富的组织中表达，如肾脏、心脏、骨骼肌和神经系统内的特定区域。通过与NoGo的相互作用，NIMP可能在NoGO诱导的轴突生长抑制中发挥作用。作为替代剪接事件的结果产生NIMP的三种异构体。