Iterative Crystallography Service：Interleukin-2 with its alpha Receptor
产品名称： Iterative Crystallography Service：Interleukin-2 with its alpha Receptor
英文名称： Iterative Crystallography Service：Interleukin-2 with its alpha Receptor
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产品价格： 询价
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http://www.creative-biostructure.com/Iterative-crystallography/Iterative-crystallography-CBCRY33.htm
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Cat. No. |
CBCRY33 |
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Background |
Interleukin-2 (IL-2) is an immunoregulatory cytokine that binds sequentially to the alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gammac) receptor subunits. |
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Molecular description |
Protein Classification |
Immune System |
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Structure Weight |
40207.9 Da |
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Polymer |
1 |
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Molecule |
Interleukin-2 |
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Chain Length |
133 amino acids |
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Polymer |
2 |
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Molecule |
Interleukin-2 receptor alpha chain |
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Chain Length |
219 amino acids |
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Crystal Description |
PDB ID |
1Z92 |
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MMDB ID |
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Source |
E.coli |
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Method |
X-Ray Diffraction |
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Resolution |
2.80 Å |
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Gene information |
Gene Name |
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Synonyms |
IL-2; TCGF; lymphokine; T cell growth factor; aldesleukin; interleukin-2; involved in regulation of T-cell clonal expansion; Aldesleukin |
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UniProt ID |
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GeneID |
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Chromosome Location |
4q26-q27 |
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Function |
cytokine activity; interleukin-2 receptor binding; protein binding; growth factor activity; kinase activator activity |
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Gene Name |
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Synonyms |
RP11-536K7.1; CD25; IDDM10; IL2R; TCGFR; Interleukin-2 receptor; OTTHUMP00000019030; OTTHUMP00000044870; interleukin 2 receptor, alpha chain; IL-2-RA; IL2-RA; CD25 antigen; IL2 receptor alpha subunit; TAC antigen; interleukin 2 receptor, alpha |
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UniProt ID |
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GeneID |
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Chromosome Location |
10p15-p14 |
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Reference |
Rickert, M., Wang, X., Boulanger, M.J., Goriatcheva, N., Garcia, K.C. (2005) The structure of interleukin-2 complexed with its alpha receptor. Science 308: 1477-1480 |
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