FITC标记的G蛋白偶联受体12抗体
产品名称： FITC标记的G蛋白偶联受体12抗体
英文名称： Anti-GPR12/FITC
产品编号： HZ-13514R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围：
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
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Rabbit Anti-GPR12/FITC Conjugated antibody
FITC标记的G蛋白偶联受体12抗体
| 英文名称 | Anti-GPR12/FITC |
| 中文名称 | FITC标记的G蛋白偶联受体12抗体 |
| 别 名 | FLJ18149; FLJ97704; G protein coupled receptor 12; G-protein coupled receptor 12; GPCR12; GPCR21; GPR 12; GPR12; GPR12_HUMAN; MGC138349; MGC138351; Probable G protein coupled receptor GPR12; GPCR GPR12. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 37kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human G protein coupled receptor 12 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intracellular signal (G protein activation). GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. All of the receptors have seven membrane-spanning domains and the extracellular parts of the receptor can be glycosylated. These extracellular loops also contain two highly conserved cysteine residues which create disulfide bonds to stabilize the receptor structure. GPR12 is a 334 amino acid peptide that is expressed primarily in brain, particularly in regions where neuronal differentiation takes place. GPR12 is coupled to an inhibitory G protein. It positively influences differentiation and maturation of post-mitotic neurons, and it may promote the growth of neuronal precursor cells. Function: Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production. Subcellular Location: Cell membrane. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 2835 Human Entrez Gene: 14738 Mouse Entrez Gene: 80840 Rat Omim: 600752 Human SwissProt: P47775 Human SwissProt: P35412 Mouse SwissProt: P30951 Rat Unigene: 123034 Human Unigene: 153539 Mouse Unigene: 88417 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
G蛋白偶联受体(GPR)是跨膜受体的蛋白家族，将细胞外信号(配体结合)传递到细胞内信号(G蛋白激活)。GPR信号是所有真核生物用来感知环境刺激并介导细胞-细胞通讯的进化古老机制。所有的受体都有七个跨膜结构域，受体的胞外部分可以糖基化。这些细胞外环还含有两个高度保守的半胱氨酸残基，它们产生二硫键以稳定受体结构。GPR12是一种334氨基酸肽，主要表达于大脑，特别是在神经元分化发生的区域。GPR12与抑制性G蛋白偶联。它对有丝分裂后神经元的分化和成熟有积极影响，并可促进神经元前体细胞的生长。