FITC标记的乳腺癌相关蛋白1抗体
产品名称： FITC标记的乳腺癌相关蛋白1抗体
英文名称： Anti-BCAS1/FITC
产品编号： HZ-11462R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-BCAS1/FITC Conjugated antibody
FITC标记的乳腺癌相关蛋白1抗体
| 产品编号 | bs-11462R-FITC |
| 英文名称 | Anti-BCAS1/FITC |
| 中文名称 | FITC标记的乳腺癌相关蛋白1抗体 |
| 别 名 | NABC1; AIBC 1; AIBC1; Amplified and overexpressed in breast cancer; BCAS 1; BCAS1; BCAS1_HUMAN; Breast carcinoma amplified sequence 1; Breast carcinoma-amplified sequence 1; Novel amplified in breast cancer 1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 62kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human BCAS1 (542-584aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene resides in a region at 20q13 which is amplified in a variety of tumor types and associated with more aggressive tumor phenotypes. Among the genes identified from this region, it was found to be highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. However, this gene is not in the common region of maximal amplification and its expression was not detected in the breast cancer cell line MCF7, in which this region is highly amplified. Although not consistently expressed, this gene is a candidate oncogene. [provided by RefSeq, Jul 2008] Function: Expressed in brain and prostate, and at lower levels in testis, intestine and colon. Overexpressed in most breast cancer cell lines and down-regulated in some colorectal tumors. Subunit: Homodimer. May interact with DYNLL1 and DYNLL2 Subcellular Location: Cytoplasm. Tissue Specificity: Expressed in brain and prostate, and at lowerlevels in testis, intestine and colon. Overexpressed in most breastcancer cell lines and down-regulated in some colorectal tumors. Database links: Entrez Gene: 8537 Human Omim: 602968 Human SwissProt: O75363 Human Unigene: 728940 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因位于20q13的区域，该区域在多种肿瘤类型中扩增，并与更具侵袭性的肿瘤表型相关。在从该区域鉴定的基因中，发现在3个扩增的乳腺癌细胞系和在一个乳腺肿瘤中没有在20q132扩增的高表达。然而，该基因不在最大扩增的共同区域中，在乳腺癌细胞系MCF7中未检测到其表达，该区域被高度扩增。该基因虽不一致表达，但仍为候选癌基因。