Semaphorin 5A,跨膜蛋白SEMA5A抗体

产品编号HZ-11481R
英文名称Semaphorin 5A
中文名称跨膜蛋白SEMA5A抗体
别 名Semaphorin 5A; Semaphorin-5A; Semaphorin5A; SEMA5A; SEMAF; Semaphorin F; SEM5A_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 细胞膜蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
Semaphorin 5A,跨膜蛋白SEMA5A抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量118kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human SEMA5A/Semaphorin 5A
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Semaphorin 5A,跨膜蛋白SEMA5A抗体PubMedPubMed
产品介绍background:
This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.

Function:
Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.

Subunit:
Binds PLXNB3.

Subcellular Location:
Membrane; single-pass type I membrane protein

Semaphorin 5A,跨膜蛋白SEMA5A抗体Similarity:
Belongs to the semaphorin family.
Contains 1 PSI domain.
Contains 1 Sema domain.
Contains 7 TSP type-1 domains.

Gene ID:
9037

Database links:
Entrez Gene: 9037 Human
Entrez Gene: 20356 Mouse
Omim: 609297 Human
SwissProt: Q13591 Human
SwissProt: Q62217 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.