FGF3,FGF4/CEN11p FISH Probe
产品名称： FGF3,FGF4/CEN11p FISH Probe
英文名称： FGF3,FGF4/CEN11p FISH Probe
产品编号： FG0058
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Labeled FISH probes for identification of gene amplification using Fluoresecent In Situ Hybridization Technique. (Technology)
- Storage Instruction:
- Store at 4°C in the dark.
- Quality Control Testing:
- Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
- Supplied Product:
- DAPI Counterstain (1500 ng/mL ) 250 uL
- Note:
- Hybridization position of the probes on the chromosome:
-
- Probe 1:
Size:
Fluorophore:
Location: - FGF3,FGF4
Approximately 320kb
Texas Red
11q13.3
- Probe 2:
Size:
Fluorophore:
Location: - CEN11p
Approximately 630kb
FITC
11p11.12
- Probe Gap:
- The gap between two probes is approximately 21,900 kb.
- Origin:
- Human
- Source:
- Genomic DNA
- Regulation Status:
- For research use only (RUO)
- Applications
- Fluorescent In Situ Hybridization (Cell)
- Protocol Download
- Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
enlarge this image- Human stomach carcinoma (FFPE) stained with FGF3,4/CEN11p FISH Probe. Human stomach carcinoma showed FGF3,4 gene amplification (FGF3,4/CEN11p ratio ≥ 2).
- Protocol Download
- Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
enlarge this image- Human breast cancer (FFPE) stained with FGF3,FGF4/CEN11p FISH Probe. Human breast cancer showed no FGF3,FGF4 genes amplification
- Protocol Download
- Entrez GeneID:
- 2248
- Gene Name:
- FGF3
- Gene Alias:
- HBGF-3,INT2
- Gene Description:
- fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq
- Other Designations:
- INT-2 proto-oncogene protein,V-INT2 murine mammary tumor virus integration site oncogene homolog,fibroblast growth factor 3,murine mammary tumor virus integration site 2, mouse,oncogene INT2
- Entrez GeneID:
- 2249
- Gene Name:
- FGF4
- Gene Alias:
- HBGF-4,HST,HST-1,HSTF1,K-FGF,KFGF
- Gene Description:
- fibroblast growth factor 4
- Omim ID:
- 164980
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq
- Other Designations:
- heparin secretory transforming protein 1,human stomach cancer, transforming factor from FGF-related oncogene,kaposi sarcoma oncogene,oncogene HST,transforming protein KS3