FITC标记的中性胆固醇酯水解酶1抗体
产品名称： FITC标记的中性胆固醇酯水解酶1抗体
英文名称： Anti-AADACL1/FITC
产品编号： HZ-5162R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-AADACL1/FITC Conjugated antibody
FITC标记的中性胆固醇酯水解酶1抗体
| 英文名称 | Anti-AADACL1/FITC |
| 中文名称 | FITC标记的中性胆固醇酯水解酶1抗体 |
| 别 名 | Arylacetamide deacetylase like 1; Arylacetamide deacetylase-like 1; Kiaa1363; NCEH; Nceh1; NCEH1_HUMAN; Neutral cholesterol ester hydrolase 1; Neutral cholesterol ester hydrolase. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 信号转导 肿瘤细胞生物标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 46kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human AADACL1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The assembly of very-low-density lipoproteins (VLDLs) in the secretory apparatus of the hepatocyte relies on the mobilization of triacylglycerol (TAG) from the cytosolic pool by lipolysis and re-esterification. However, some of the re-esterified TAG products are returned to the cytosolic pool in the liver, which protects vulnerable body tissues from excess lipotoxic non-esterified fatty acids in the plasma. Some of the lipases involved in this process include arylacetamide deacetylase (AADAC) and its related proteins AADACL1 and AADACL2. AADAC, a single pass type II membrane protein of the endoplasmic reticulum, is expressed in hepatocytes, intestinal mucosal cells, pancreas and adrenal gland. It plays an important role in the metabolic activation of arylamine substrates to ultimate carcinogens. AADACL1 hydrolyzes the metabolic intermediate 2-acetyl monoalkylglycerol, and its inactivation results in disruption of ether lipid metabolism in cancer cells and impaired cell migration and tumor growth. Function: Hydrolyzes 2-acetyl monoalkylglycerol ether, thepenultimate precursor of the pathway for de novo synthesis ofplatelet-activating factor. May be responsible for cholesterolester hydrolysis in macrophages, thereby contributing to thedevelopment of atherosclerosis. Also involved in organdetoxification by hydrolyzing exogenous organophosphorus compounds.May contribute to cancer pathogenesis by promoting tumor cellmigration. Subcellular Location: Membrane; Single-pass type II membraneprotein (Probable). Microsome Tissue Specificity: Expressed in monocyte-derived macrophages. Up-regulated in invasive melanoma and breast carcinoma cell lines. Post-translational modifications: N-glycosylated. Similarity: Belongs to the 'GDXG' lipolytic enzyme family. Database links: Entrez Gene: 57552 Human Entrez Gene: 320024 Mouse Omim: 613234 Human SwissProt: Q6PIU2 Human SwissProt: Q8BLF1 Mouse Unigene: 444099 Human Unigene: 24576 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
非常低密度lipoproteins（VLDLS）在肝细胞分泌装置中的组装依赖于通过脂肪分解和再酯化从胞质池动员三酰甘油（TAG）。然而，一些再酯化标签产品返回到肝脏中的胞浆池，这保护了脆弱的身体组织免受血浆中过量的脂毒性非酯化脂肪酸的影响。在该过程中所涉及的脂肪酶包括芳基乙酰酰胺脱乙酰酶（AADAC）及其相关蛋白AADACL1和AADACL2。AADAC是一种内质网单通道II型膜蛋白，在肝细胞、肠粘膜细胞、胰腺和肾上腺中均有表达。它在芳香胺底物对最终致癌物的代谢活化中起着重要的作用。AADACL1水解代谢中间体2-乙酰基单烷基甘油，其失活导致癌细胞中醚脂质代谢的破坏和细胞迁移和肿瘤生长受损。