FITC标记的激活素受体2A抗体
产品名称： FITC标记的激活素受体2A抗体
英文名称： Anti-Activin receptor type-2A/FITC
产品编号： HZ-12416R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Activin receptor type-2A/FITC Conjugated antibody
FITC标记的激活素受体2A抗体
| 英文名称 | Anti-Activin receptor type-2A/FITC |
| 中文名称 | FITC标记的激活素受体2A抗体 |
| 别 名 | Activin Receptor Type IIA; Activin A receptor type IIA; Activin receptor type 2A; Activin receptor type IIA; Activin receptor type-2A; ACTR 2; ACTR IIA; ACTR-IIA; ACTR2; ACTR 2; ACTR-2; ACTRII; ACTRIIA; Acvr 2; Acvr 2A; Acvr2; ACVR2A; AVR2A_HUMAN; OTTHUMP00000197918. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 干细胞 激酶和磷酸酶 结合蛋白 细胞表面分子 细胞骨架 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 56kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ACTR2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Members of the transforming growth factor b superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain serine/threonine kinases and associate to form a signaling complex (1). Activin has been shown to bind a heteromeric noncovalent complex, which consists of a type I receptor, ACTR-IA (also designated ACVRI and ALK-2) or ACTR-IB (also designated ALK-4 and SKR2), and a type II receptor, ACTR-IIA (also designated ACVR2A) or ACTR-IIB (also designated ACVR2B) (1-6). Both receptor types are highly expressed in brain (5). The activin receptor family members are thought to mediate distinct effects on gene expression, cell differentiation, and morpho- genesis in a dose dependent fashion (5,6). Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Subunit: Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 (By similarity). Subcellular Location: Membrane; Single-pass type I membrane protein. Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain. Database links: Entrez Gene: 281598 Cow Entrez Gene: 92 Human Entrez Gene: 11480 Mouse Entrez Gene: 29263 Rat Entrez Gene: 553359 Zebrafish Omim: 102581 Human SwissProt: P27037 Human SwissProt: P27038 Mouse SwissProt: P38444 Rat Unigene: 470174 Human Unigene: 314338 Mouse Unigene: 161783 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
转化生长因子b超家族的成员与一对跨膜蛋白结合，称为受体类型I和II，它们含有丝氨酸/苏氨酸激酶，并联合起来形成信号复合物(1)。激活素已显示与异源非共价复合物结合，该复合物由I型受体、ACTR-IA(也称为ACVRI和ALK-2)或ACTR-IB(也称为ALK-4和SKR2)和II型受体、ACTR-IIA(也称为ACVR2A)或ACTR-IIB(也称为ACVR2B)(1-6)组成。两种受体类型均在脑中高表达（5）。激活素受体家族成员被认为以剂量依赖的方式介导对基因表达、细胞分化和形态发生的明显影响（5，6）。