FITC标记的踝蛋白抗体
产品名称： FITC标记的踝蛋白抗体
英文名称： Anti-Talin/FITC
产品编号： HZ-3619R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Talin/FITC Conjugated antibody
FITC标记的踝蛋白抗体
| 英文名称 | Anti-Talin/FITC |
| 中文名称 | FITC标记的踝蛋白抗体 |
| 别 名 | TLN 1; ILWEQ; Talin 1; TLN; TLN1; TLN1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 转录调节因子 细胞粘附分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 280kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Talin |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Talin, a multifunctional constituent of cell-substratum attachment sites, is a high molecular weight protein (225-270 kDa) found in variety of tissues and cell types. It is localized at a subset of adherens junctions, specialized cell-cell and cell-matrix associations that are characterized by the presence of filamentous actin at the cytoplasmic face of the junctional complex. In cultured cells, talin is absent from cell-cell junctions and found predominantly at adhesion plaques and in fibrillar streaks underlying cell surface fibronectin. Talin interacts with at least two other proteins that are localized at adhesion plaques, vinculin and integrin. Talin and vinculin have been shown to interact with each other and both have been proposed to be involved in generating the transmembrane connection, between the extracellular matrix and the cytoskeleton, that occurs at adhesion plaques. At physiological ionic strength, talin is an elongate, flexible, monomeric protein with the ability to self-associate into dimers at higher protein concentrations. Function: Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts. Subunit: Binds with high affinity to VCL and with low affinity to integrins. Interacts with PTK2/FAK1 (By similarity). Interacts with PIP5K1C and NRAP. Interacts with LAYN. Interacts with SYNM. Subcellular Location: Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Colocalizes with LAYN at the membrane ruffles. Similarity: FERM domain. Contains 1 I/LWEQ domain. Database links: Entrez Gene: 395194 Chicken Entrez Gene: 7094 Human Entrez Gene: 21894 Mouse Entrez Gene: 313494 Rat Omim: 186745 Human SwissProt: P54939 Chicken SwissProt: Q9Y490 Human SwissProt: P26039 Mouse Unigene: 471014 Human Unigene: 208601 Mouse Unigene: 7715 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. TALIN-踝蛋白。是重要的细胞骨架肌动蛋白结合蛋白，由两个270kDa的亚单位组成的反向 平行的同源二聚体，与整合蛋白B尾部的结合诱导了整合蛋白胞外结构域构象的改变,起到了对整合蛋白的激活 |
TALIN是细胞基质附着位点的多功能组分，是一种高分子量蛋白（225-270 kDa），存在于多种组织和细胞类型中。它定位于粘附连接的一个子集，专门的细胞-细胞和细胞基质协会，其特征在于在连接复合体的细胞质面上存在丝状肌动蛋白。在培养的细胞中，Talin不存在于细胞-细胞连接处，主要存在于粘附斑块和纤维细胞条纹下面的细胞表面纤维连接蛋白。Talin与至少两种定位于粘附斑块、纽蛋白和整合素的蛋白相互作用。已经证明，Talin和纽蛋白相互作用，并且两者都被建议参与产生粘附膜上的细胞外基质和细胞骨架之间的跨膜连接。在生理离子强度方面，Talin是一种细长的、柔性的单体蛋白质，具有在较高蛋白质浓度下自缔合成二聚体的能力。