FITC标记的间隙连结蛋白31.9抗体
产品名称： FITC标记的间隙连结蛋白31.9抗体
英文名称： Anti-GJC1/FITC
产品编号： HZ-13365R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GJC1/FITC Conjugated antibody
FITC标记的间隙连结蛋白31.9抗体
| 英文名称 | Anti-GJC1/FITC |
| 中文名称 | FITC标记的间隙连结蛋白31.9抗体 |
| 别 名 | Connexin-31.9; Connexin 31.9; Cx30.2; Cx31.9; CXD3_HUMAN; Gap junction alpha-11 protein; Gap junction chi-1 protein; Gap junction delta-3 protein; Gap junction protein 31.9-kD; Gap junction protein CHI-1; Gap junction protein, alpha-11; Gap junction protein, delta 3, 31.9kDa; Gap junction delta-3 protein; Gap junction protein, delta-3; GJA11; GJC1; Gjd3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 细胞粘附分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 32kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Connexin 31.9 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈. |
| 产品介绍 | background: The connexin family of proteins form hexameric complexes, called connexons, that facilitate movement of low molecular weight proteins between cells via gap junctions. Connexin proteins share a common topology of four transmembrane ?helical domains, two extracellular loops, a cytoplasmic loop and cytoplasmic N- and C-termini. Many of the key functional differences arise from specific amino acid substitutions in the most highly conserved domains; the transmembrane and extracellular regions. Connexin 31.9, also known as GJD3 (Gap junction delta-3 protein), is a 294 amino acid protein that interacts with ZO-1, a tight junction protein. Connexin 31.9 is expressed in heart, brain, kidney, spleen, lung, testis, colon and vascular smooth muscle cells. There are two isoforms of connexin 31.9 that are produced as a result of alternative splicing events. Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Subunit: A connexon is composed of a hexamer of connexins (By similarity). Interacts with TJP1. Subcellular Location: Cell membrane. Cell junction; gap junction. Tissue Specificity: Expressed in vascular smooth muscle cells. Found in heart, colon, and artery (at protein level). Found in cerebral cortex, heart, liver, lung, kidney, spleen and testis. Similarity: Belongs to the connexin family. Delta-type subfamily. Database links: UniProtKB/Swiss-Prot: Q8N144.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
连接蛋白家族形成六聚体复合物，称为连接子，通过间隙连接促进低分子量蛋白质在细胞间的移动。连接蛋白蛋白具有四跨膜的共同拓扑结构？螺旋结构域，两个胞外环，细胞质环和细胞质的N-和C-末端。许多关键的功能差异产生于高度保守的区域，即跨膜和细胞外区域的特定氨基酸取代。连接蛋白31.9，也称为GJD3（间隙连接δ-3蛋白），是一种294个氨基酸的蛋白质，与紧密连接蛋白ZO-1相互作用。连接蛋白31.9在心脏、脑、肾、脾、肺、睾丸、结肠和血管平滑肌细胞中均有表达。作为替代剪接事件的结果，产生连接蛋白31.9的两种亚型。