FITC标记的博莱霉素水解酶抗体
产品名称： FITC标记的博莱霉素水解酶抗体
英文名称： Anti-BLMH/FITC
产品编号： HZ-11654R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-BLMH/FITC Conjugated antibody
FITC标记的博莱霉素水解酶抗体
| 产品编号 | bs-11654R-FITC |
| 英文名称 | Anti-BLMH/FITC |
| 中文名称 | FITC标记的博莱霉素水解酶抗体 |
| 别 名 | BH; bleomycin hydrolase; BLM hydrolase; BMH; EC 3.4.22.40; BLMH_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 Alzheimer's |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 53kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human BLMH (308-400aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. [provided by RefSeq, Jul 2008]. Function: BLMH is a member of the peptidase C1 family and exists as a homohexamer. While its normal physiological function is not known, it protects normal and malignant cells from the glycopeptide antitumor drug BLM. It inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine and also shows general aminopeptidase activity. The specificity varies but amino acid arylamides of Met, Leu and Ala are preferred. Subunit: Homohexamer. Subcellular Location: Cytoplasmic Similarity: Belongs to the peptidase C1 family. Database links: UniProtKB/Swiss-Prot: Q13867. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
Bleomycin hydrolase（BMH）是一种通过进化而高度保守的细胞质半胱氨酸肽酶，然而，酶的唯一已知活性是糖肽博来霉素（BLM）的代谢失活，这是癌症联合化疗方案的重要组成部分。该蛋白含有半胱氨酸蛋白酶木瓜蛋白酶超家族的标志性活性位点残基。