Introduction For protein peptide and other biomolecule purification

Cellufine Ion Exchangers are based on spherical particles manufactured from crosslinked cellulose. Each offers excellent flow properties, mechanical stability and chemical resistance. These ion exchangers are ideally suited for both laboratory and process scale chromatography of proteins, peptides and other biomolecules. Applications include the purification of antibodies, growth factors, albumin, enzymes, nucleic acids, etc.

Features • Spherical particles exhibiting high mechanical strength • Choice of several pore sizes • Hydrophilic • DEAE (A), QA (Q) anion exchange and carboxylmethyl (C) cation exchange • Pre-swollen • Virtually no shrinkage or swelling • Resistant to 0.5M NaOH • Stable in organic solvents • Autoclavable (121 °C for 30 minutes) • Passes USP V tests (A-500, C-500)

Benefits • High flow rates allowing rapid chromatography and direct scale-up • Allows optimum capacity matched to molecular weight • Low non-specific binding • Optimal functionality selection • Easy packing

• Easy large scale operation • Easy regeneration and depyrogenation • Allows alternative cleaning regimes • Sterilizable • Non toxic • Regulatory support