FITC标记的精神分裂症与犰狳重复基因抗体
产品名称： FITC标记的精神分裂症与犰狳重复基因抗体
英文名称： Anti-ARVCF/FITC
产品编号： HZ-12532R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ARVCF/FITC Conjugated antibody
FITC标记的精神分裂症与犰狳重复基因抗体
| 英文名称 | Anti-ARVCF/FITC |
| 中文名称 | FITC标记的精神分裂症与犰狳重复基因抗体 |
| 别 名 | Armadillo repeat gene deletes in velocardiofacial syndrome; Armadillo repeat protein; Armadillo repeat protein deleted in velo cardio facial syndrome; Armadillo repeat protein deleted in velo-cardio-facial syndrome; ARVC_HUMAN; Arvcf; FLJ35345; OTTHUMP00000028704; OTTHUMP00000198346; OTTHUMP00000198347; OTTHUMP00000198348. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 105kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ARVCF |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Armadillo Repeat gene deleted in Velo-Cardio-Facial syndrome (ARVCF) is a member of the catenin family. This family plays an important role in the formation of adherens junction complexes, which are thought to facilitate communication between the inside and outside environments of a cell. The ARVCF gene was isolated in the search for the genetic defect responsible for the autosomal dominant Velo-Cardio-Facial syndrome (VCFS), a relatively common human disorder with phenotypic features including cleft palate, conotruncal heart defects and facial dysmorphology. The ARVCF gene encodes a protein containing two motifs, a coiled coil domain in the N-terminus and a 10 armadillo repeat sequence in the midregion. Since these sequences can facilitate protein-protein interactions ARVCF is thought to function in a protein complex. In addition, ARVCF contains a predicted nuclear-targeting sequence suggesting that it may have a function as a nuclear protein. [provided by RefSeq, Jun 2010]. Function: Involved in protein-protein interactions at adherens junctions. Subunit: Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain). Tissue Specificity: Found in all the examined tissues including heart, brain, liver and kidney. Found at low level in lung. Similarity: Belongs to the beta-catenin family. Contains 10 ARM repeats. Database links: Entrez Gene: 421 Human Omim: 602269 Human SwissProt: O00192 Human Unigene: 699354 Human Unigene: 713616 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
维拉-心面部综合征（ARVCF）缺失的犰狳重复基因是连环蛋白家族的成员。该家族在粘附连接复合物的形成中起着重要作用，粘附连接复合物被认为有助于细胞内外环境之间的交流。为了寻找导致常染色体显性Velo-Cardio-Facial综合征(VCFS)的遗传缺陷，分离了ARVCF基因，该VCFS是一种相对常见的人类疾病，具有包括腭裂、心梗和面部畸形的表型特征。ARVCF基因编码一个包含两个基序的蛋白质，一个在N末端的螺旋结构域和一个在中部区域的10个犰狳重复序列。由于这些序列可以促进蛋白质-蛋白质相互作用，因此ARVCF被认为在蛋白质复合物中起作用。此外，ARVCF包含预测的核靶向序列，提示它可能具有核蛋白的功能。[ RefSeq，Jun 2010提供]。