FITC标记的白喉酰胺生物合成样蛋白2抗体-抗体-抗体-生物在线
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FITC标记的白喉酰胺生物合成样蛋白2抗体

FITC标记的白喉酰胺生物合成样蛋白2抗体

商家询价

产品名称： FITC标记的白喉酰胺生物合成样蛋白2抗体

英文名称： Anti-DPH2/FITC

产品编号： HZ-

产品价格： null

产品产地： 中国/上海

品牌商标： HZbscience

更新时间： 2023-08-17T10:24:20

使用范围： IF=1:50-200

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 Rabbit Anti-DPH2/FITC Conjugated antibody

FITC标记的白喉酰胺生物合成样蛋白2抗体

 

产品编号 bs-8282R-FITC
英文名称 Anti-DPH2/FITC
中文名称 FITC标记的白喉酰胺生物合成样蛋白2抗体
别    名 Diphthamide biosynthesis like protein 2; Diphthamide biosynthesis protein 2; Diphthamide biosynthesis protein 2 homolog like 2; Diphthamide biosynthesis protein 2 homolog-like 2; Diptheria toxin resistance protein required for diphthamide biosynthesis like 2; Diptheria toxin resistance protein required for diphthamide biosynthesis like 2 S. cerevisiae ; DPH 2; DPH2; DPH2 homolog; DPH2 homolog S. cerevisiae; DPH2 like 2; DPH2 like 2 S. cerevisiae; DPH2-like 2; DPH2_HUMAN; DPH2L2; HsDph2; OTTHUMP00000010007; Protein DPH2 homolog.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  免疫学  细胞膜受体  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 52kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DPH2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
DPH2 (diphthamide biosynthesis protein 2), also known as DPH2L2, is a 489 amino acid protein that shows strong expression in skeletal muscle; moderate expression in heart, small intestine, liver, pancreas, testis and colon; and lesser expression in brain, placenta, kidney, spleen, thymus, prostate, ovary and lymphocytes. DPH2 interacts with DPH1 and, functioning together as a dimer or multimer, DPH1 and DPH2 may participate in diphthamide biosynthesis. Diphthamide is a posttranslationally modified histidine residue which occurs in EF-2 (elongation factor 2) and targets diphtheria toxin ADP-ribosylation. The loss of DPH2 in Saccharomyces cerevisiae is believed to suppress zymocicity. Two transcript variants encoding different isoforms have been found for this gene.
Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2.
Tissue specificity:
Strongly expressed in skeletal muscle. Moderately expressed in heart, small intestine, liver, pancreas, testis and colon. Weakly expressed in brain, placenta, kidney, speen, thymus, prostate, ovary and lymphocytes.

Function:
Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (By similarity). 

Subunit:
Interacts with DPH1 (By similarity). 

Tissue Specificity:
Strongly expressed in skeletal muscle. Moderately expressed in heart, small intestine, liver, pancreas, testis and colon. Weakly expressed in brain, placenta, kidney, speen, thymus, prostate, ovary and lymphocytes. 

Similarity:
Belongs to the DPH1/DPH2 family. DPH2 subfamily. 

Database links:
UniProtKB/Swiss-Prot: Q9BQC3.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application
   

DPH2（二基酰胺生物合成蛋白2），又称DPH2L2，是一种在骨骼肌中具有强表达的489氨基酸蛋白，在心脏、小肠、肝脏、胰腺、睾丸和结肠中呈中度表达；在脑、胎盘、肾、脾、胸腺、前列腺中表达较少；卵巢和淋巴细胞。DPH2与DPH1相互作用，作为二聚体或多聚体一起发挥作用，DPH1和DPH2可参与二甲酰胺的生物合成。二甲酰胺是翻译后修饰的组氨酸残基，其发生在EF-2（延伸因子2）和靶白喉毒素ADP-核糖基化中。DPH2在酿酒酵母中的损失被认为是抑制酵母菌性的。发现了两个编码不同亚型的转录变体。

在合成二基酰胺中需要的第一步，即翻译延伸因子2中发生的组氨酸翻译后修饰。

组织特异性：

 

在骨骼肌中强烈表达。在心脏、小肠、肝脏、胰腺、睾丸和结肠中度表达。在脑、胎盘、肾脏、SPEN、胸腺、前列腺、卵巢和淋巴细胞中表达较弱。