FITC标记的磷酸化220kDa蛋白激酶D相互作用蛋白抗体
产品名称： FITC标记的磷酸化220kDa蛋白激酶D相互作用蛋白抗体
英文名称： Anti-phospho-Kidins220 (Ser918)/FITC
产品编号： HZ-7041R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-phospho-Kidins220 (Ser918)/FITC Conjugated antibody
FITC标记的磷酸化220kDa蛋白激酶D相互作用蛋白抗体
| 英文名称 | Anti-phospho-Kidins220 (Ser918)/FITC |
| 中文名称 | FITC标记的磷酸化220kDa蛋白激酶D相互作用蛋白抗体 |
| 别 名 | Kidins220 (phospho S918); Ankyrin repeat-rich membrane-spanning protein; arms; KDIS_HUMAN; Kidins220; Kinase D interacting substance of 220 kDa; Kinase D-interacting substrate of 220 kDa; rgd 619949. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 心血管 细胞生物 免疫学 神经生物学 信号转导 转录调节因子 激酶和磷酸酶 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit, Guinea Pig, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 196kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human Kidins220 around the phosphorylation site of Ser918 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. Function: ’Promotes a prolonged MAP-kinase signaling byneurotrophins through activation of a Rap1-dependent mechanism.Provides a docking site for the CRKL-C3G complex, resulting inRap1-dependent sustained ERK activation. May play an important rolein regulating postsynaptic signal transduction through thesyntrophin-mediated localization of receptor tyrosine kinases suchas EPHA4. In cooperation with SNTA1 can enhance EPHA4-inducedJAK/STAT activation. May play a role in neurotrophin- andephrin-mediated neuronal outgrowth and in axon guidance duringneural development and in neuronal regeneration (By similarity).Modulates stress-induced apoptosis of melanoma cells via regulationof the MEK/ERK signaling pathway. Subunit: nteracts with NTRK1, NTRK2, NTRK3, ERKL and NGFR. Canform a ternary complex with NGFR and NTRK1 and this complex isaffected by the expression levels of KIDINS220/ARMS. An increase inKIDINS220/ARMS expression leads to a decreased association of NGFRand NTRK1. Interacts with SNTA1 and SNTB2 and binds to their PDZdomains. Interacts with EPHA4 and PRKD1 (By similarity). Subcellular Location: Membrane. Tissue Specificity: Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines. Post-translational modifications: Tyrosine phosphorylated by NTRK1, NTRK2, EPHB2 and EPHA4.Phosphorylation at Ser-918 is induced by phorbol ester treatment.Phosphorylation by NTRK2 is induced by brain-derived neurotrophicfactor (BDNF) and neurotrophin-4/5. Phosphorylation by NTRK1 isinduced by nerve growth factor (NGF) (By similarity). Similarity: Contains 12 ANK repeats. Contains 1 KAP NTPase domain. Database links: Entrez Gene: 57498 Human Entrez Gene: 77480 Mouse Entrez Gene: 116478 Rat SwissProt: Q9ULH0 Human SwissProt: Q9EQG6 Rat Unigene: 9873 Human Unigene: 250641 Mouse Unigene: 21470 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
通过激活RAP1依赖的机制促进神经营养素延长MAP激酶信号传导。为CRKL - C3G复合物提供对接位点，导致RAP1依赖的持续ERK激活。可能通过调节合成酪氨酸激酶如EPHA4在调节突触后信号转导中发挥重要作用。与SNTA1协同作用可增强EPHA4诱导的JAK/STAT活化。在神经发育和神经再生过程中（如相似度）中，神经营养素和埃弗林介导的神经元生长和轴突引导可能起作用。通过调节MEK/ERK信号通路调节应激诱导黑色素瘤细胞凋亡。